10        20        30        40        50        60        70        80        90       100       110       120                    
                           ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
Homo sapiens               MSFRGGGRGGFNRGGGGGGFNRGG~SSNHFRGGGGGGGG~~~~~~~~~~GNFRGGGRGGFGRGGGRGGFNKGQDQGPPERVVLLGEFLHPCEDDIVCKCTTDENKVPYFNAPVYLENKEQ 
Mus musculus               MSFRGGGRGGFNRGGGGGGFNRGGGSNNHFRGGGGGGGGSFRGGGGGGGGSFRGGGRGGFGRGGGRGGFNKFQDQGPPERVVLLGEFMHPCEDDIVCKCTTEENKVPYFNAPVYLENKEQ 
Schizosaccharomyces pombe  MS~~~~~~~~~~~~~~~~~~~~~~~~~~~FRGG~RG~~~~~~~~~~~~~~~~~GGFRGGRGG~~~~~~SRPFTPSGPPDQVIELGLFMHDCEGEMVCQ~STNVK~IPYFNAPIYLENKSQ 
Saccharomyces cerevisiae   MS~~~~~~~~~~~~~~~~~~~~~~~~~~~FRGGNRGG~~~~~~~~~~~~~~~RGGFRGGFRG~GRTGSARSFQ~QGPPDTVLEMGAFLHPCEGDIVCR~SINTK~IPYFNAPIYLENKTQ 
Candida glabrata           MS~~~~~~~~~~~~~~~~~~~~~~~~~~~FRGGFRGG~~~~~~~~~~~~~~~RGGSRGGFGGRGGARGGRPIQ~QGPPDTVLEMGEFMHPCEGDVVCR~SINTK~VPYFNAPIYLENKTQ 
Ashbya gossypii            MS~~~~~~~~~~~~~~~~~~~~~~~~~~~FRGNSRGG~~~~~~~~~~~~~~~RGGARGGSRGGRGGFGGRQFQ~QGPPDSVVEMGAFMHDCEGDIVCR~SINTK~IPYFNAMIYLENKTE 
Tetrahymena thermophila    M~AK~DFKSAANNAG~~~~~~~~~~PRKDFRQGGGNAGG~~~~~~~~~~~~~~~~~RGGFNKGGNFRGNNN~RDMGPPERVEPVCVFSHTCGDQIVVKAT~DVKKVPKFNRGIYLENKTK 
Cryptosporidium parvum     MS~~~~~~~~~~~~~~~~~~~~~~~~~~~ARG~SRG~~~~~~~~~~~~~~NFRGG~RGSSRGKGGVPSNGRPSFSGPPSSITELGEVLHSSEHELVCKSFLNDQ~VPYFNGRIFLENKEE 
Trypanosoma cruzi          MT~~~~~~~~~~RGGGGG~~~~~~~~~~~FGRGGGGGRG~~~~~~~~~~~~~FGGPRGGRGG~~GGRGGREAE~PDPPESLELIGTFMNAAEGYLVYKVTIPEV~VPRFNAFVYTENRAK 

                                   130       140       150       160       170       180       190       200       210       220       230       240           
                           ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
Homo sapiens               IGKVDEIFGQLRDFYFSVKLSENMKASSFKKLQKFYIDPYKLLPLQRFLPRPPGEKGPPRGGG~~~~~~RGGRGGGRGG~~GG~~~~~~RGGGRG~~~~~~~~~GGFRGGRGGGGGGF~R 
Mus musculus               VGKVDEIFGQLRDFYFSVKLSENMKASSFKKLQKFYIDPYKLLPLQRFLPRPPGEKGPPRGGGG~~~GGRGGRGGGRGG~~GG~~~~~~RGGGRG~~~~~~~~~GGFRGGRGGGGG~F~R 
Schizosaccharomyces pombe  IGKIDEVFGPMNQVYFTVKPSEGIVSSSFKVGDKVYLSGDKLIPLDRFLPKPKTVGPKKP~~~~KGARNGPAGRGGRGGFR~~~~~~GGRGGSRGGFG~~GNSRGGFG~~GGSRGGFG~~ 
Saccharomyces cerevisiae   VGKVDEILGPLNEVFFTIKCGDGVQATSFKEGDKFYIAADKLLPIERFLPKPKVVGPPKP~~~~KNKKKRSGAPGGRGGAS~~~~~~MGRGGSRGGF~~RGG~RGGSSFRGG~RGGSSFR 
Candida glabrata           VGKVDEILGPLNEVYFTIKCGEGVQATSFKEGDKFYIAPDKLLPIERFIPKPKVAGPPKP~~~~KNKKKRSGAPAGRGGARGG~~~FGGRGGSRGGFGGRGGSRGGFGGRGGSRGGFGGR 
Ashbya gossypii            VGKVDEILGPLNEVFFTIKCAEGVKASSFKDGDKFYISPEKLLPIERFIPKPKVAGPPKP~~~~KRKRAAGGAP~GRGGFG~~~~~~~GRGGSRGGFGGRGGARGGFGGRGGARGGFGGF 
Tetrahymena thermophila    VGTVDEILGPIDGFYYSIKLVEGVSADSYKPGDKFYMGWDDTLPIDRFLPKPKGAGGPRR~~~GPGGIQKGGPGG~RGGFQ~~~~~~~~KGGFNNNNN~~~~~KGGFNKGGFNKGGFN~K 
Cryptosporidium parvum     IGKVDEILGPINTYFFSIKMNNGVKAESFVTGTKIFIDPQQLLPMSRFLPKPSTQKTTKK~~~~~~~~TGEAAIGKKRGFN~~~~~~~~GSPGRGGQS~RG~VRGRGFARGASPRGFRGR 
Trypanosoma cruzi          IGKIDEVMGNTTDVMFSVMPMPGVQAGSISEGDNIFVSPTQLTPVRVFTDPPKPRGRGGRGGGGRGGRSANGGGSSRGNFGGGGRGNFGGGSSRGNFG~~GGGRGNFGG~GSSRGSFGGG 

                                   250       260       270       280   
                           ....|....|....|....|....|....|....|....|..
Homo sapiens               GG~RGGG~FRGRGH~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 
Mus musculus               GG~RGGGGFRGRGH~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 
Schizosaccharomyces pombe  GGSRGG~~SRGGFRG~~GSRG~~~~GFRGRF~~~~~~~~~~~ 
Saccharomyces cerevisiae   GGSRG~~~~~GSFRG~~GSRG~~~~GSRGGF~~RGGRR~~~~ 
Candida glabrata           GGSRGGFGGRGGSRGGFGGRG~~~~GSRGGFGGRGGRS~~~~ 
Ashbya gossypii            GG~RGG~~SRGGFGGRGGARG~~~~GSRGG~~~RGGKRF~~~ 
Tetrahymena thermophila    GG~NAGG~FKKNFKN~~~~~~~~~~~~~~~~~~~~~~~~~~~ 
Cryptosporidium parvum     GTSS~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 
Trypanosoma cruzi          GRGNFGGGGRGNFGG~~GGRGNYGGGGRGNYGGGGRGNGRGY