10        20        30        40        50        60        70        80        90       100       110       120                    
                           ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
Homo sapiens (A)           MAEGLERVRISASELRGILATLAPQAGSRENMKELKEARPRKDNRRPDLEIYKPGLSRLRNKPKIKEPPGSEEFKDEIVNDRDCSAVENG-TQPVKDVCKELNNQEQNGPIDPENNRGQE 
Homo sapiens (B)           ----------------------------------MSQGPPTGESSEPEAKVLHT---------KRLYRAVVEAVHRLDLILCNKTAYQEVFKPENISLRNKLRELCVKLMFLHPVDYGRK 
Caenorhabditis elegans     -------------------------MNGDTDASSSRTGAPRKP--RPEIQIYRPGMLRQGGSTKSLSSTNEEARPPRPEKLNTTTTTMSGNSRRRSNDTDSVTSRGGSGSTTPDANVINA 
Schizosaccharomyces pombe  ------------------------------------------------------------------------------------------------------------------------ 
Saccharomyces cerevisiae   --------------------------------------MDNEEVNEECMRLFFKN-------------ARAHLDKHLTSRLTCDENAYITFRCFLDGIHRKSTRFLEELLLKQENMYHNN 

                                   130       140       150       160       170       180       190       200       210       220       230       240           
                           ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
Homo sapiens (A)           SFPRTAGQEDRSLKIIKRTKKPDLQIYQPGRRLQTVSKESASRVEEEEVLNQVEQLRVEEDECRGNVAKEEVANKPDRAEIEKSPGGGRVGAAKGEKGKRMGKGEGVRETHDDPARGRPG 
Homo sapiens (B)           AEELLWRKVYYEVIQLIKTNKKHIHSRSTLECAYRTHLVAG-----------IGFYQHLLLYIQSHYQLELQCCIDWTHVTDPLIGCKKPVSASGKE-----------------MDWAQM 
Caenorhabditis elegans     MNERGGGRNRFEKGYRQQQRTDGPSNYNSTQSLYDTRQHGG----------YMEYQGNHRSNHRNNGRYSNQQHQQHRQPFER-PGGNHYTRGFNERASMRGDG---------AIARRPQ 
Schizosaccharomyces pombe  ------------------------------------------------------------------------------------------------------------------------ 
Saccharomyces cerevisiae   NYERINDSVIPLVLKLLWLQIHEPTLQWFEHWFHDIMRLSN-----------RRKFRVFRIFQKKMIQFFKITHRYYYDIIEHLCAKYDMN----------------------------- 

                                   250       260       270       280       290       300       310       320       330       340       350       360           
                           ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
Homo sapiens (A)           SAKRYSRSDKRRNRYRTRSTSSAGSNNSAEGAGLTDNGCRRRRQDRTKERPRLKKQVSVSSTDSLDEDRIDEPDGLGPRRSSERKRHLERNWSGRGEGEQKTSAKEYRGTLRVTFDAEAM 
Homo sapiens (B)           ACHRCLVYLGDLSRYQNELAG---VDT--------ELLAERFYYQALSVAPQIGMPFNQLGTLAGSKYYN---------------------------------VEAMYCYLRCIQSEVSF 
Caenorhabditis elegans     GSRRQRNDSINSYNPRVLYQRTRGAN---------DENHPKRRDAAVEKKPKEPRRYRGEHDDRDDD------------------------------------ASEYHGTLENHMSSGRL 
Schizosaccharomyces pombe  --------------------------------------------------------------------------------------------------------------MSQQLSSNEI 
Saccharomyces cerevisiae   --------------------------------------------------------------------------------------------------------SVISNALFAKLNLMQY 

                                   370       380       390       400       410       420       430       440       450       460       470       480           
                           ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
Homo sapiens (A)           NKESPMVRSARDDMDRGKPDKGLSSGGKGSEKQESKNPKQELRGRGRGILILPAHTTLSVNSAGSPESAPLGPRLLFGSGSKGSRSWGRGGTTRRLWDPNNPDQKPALKTQTPQLHFLDT 
Homo sapiens (B)           EGAYGNLKRLYDKAAKMYHQLKKCETRKLSPGKKRCKDIKRLLVN--------------------------------------------------------------------------- 
Caenorhabditis elegans     AGRIQIVQRSQNGTEAGGNRNRQSSEEKPRTYQKRSQNQSEMANR--------------------------------------------------------------------------- 
Schizosaccharomyces pombe  CEEQGKLVKALCEAAQGGFKHDLYEKIIAIEIEVEKKLLN-------------------------------------------------------------------------------- 
Saccharomyces cerevisiae   TDGLSTHEKIILNTSNPLTFSIVISLQRCVINLGSTHFYKTLLNK--------------------------------------------------------------------------- 

                                   490       500       510       520       530       540       550       560       570       580       590       600           
                           ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
Homo sapiens (A)           DDEVSPTSWGDSRQAQASYYKFQNSDNPYYYPRTPGPASQYPYTGYNPLQYPVGPTNGVYPGPYYPGYPTPSGQYVCSPLPTSTMSPEEVEQHMRNLQQQELHRLLRVADNQELQLSNLL 
Homo sapiens (B)           ----------------------------------------------------------------------------------FMYLQSLLQPKSSSVDSELTSLCQSVLEDFNLCLFYLP 
Caenorhabditis elegans     --------------------------------------------------------------------------------------AEINRRRQEDIDRNEGKQIREISEKIEKLSAPVK 
Schizosaccharomyces pombe  --------------------------------------------------------------------------------------------RLKSIQTNTFERPDIIWSCCHYKIIQHF 
Saccharomyces cerevisiae   ----------------------------------------------------------------------------------------------PSNKPKSVEGFEKSIRYLNIASLYLP 

                                   610       620       630       640       650       660       670       680       690       700       710       720           
                           ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
Homo sapiens (A)           SRDRISPEGLEKMAQLR----AELLQLYERCILLDIEFSDNQNVDQILWKNAFYQVIEKFRQLVKDPNVENPEQIRNRLLELLDEGSDFFDSLLQKLQVTYKFKLEDYMDG--------- 
Homo sapiens (B)           SSPNLSLASEDEEEYESGYAFLPDLLIFQMVIICLMCVHSLERAGSKQYSAAIAFTLALFSHLVNHVNIR----LQAELEEGENPVPAFQSDGTDEPESKEPVEKEEEPDP--------- 
Caenorhabditis elegans     KRD---LKSAEKMAEIS----MELANIYSQVIIHDVIYSFTAGLEQKLFRQAFYKCIESLRTGS-NSAAPDARLIRAVTQKLLLNGIVYYENLIATYETQFHVALTDALTWQSGSPSDEE 
Schizosaccharomyces pombe  RSRFREIHPRHVVEKKK----------------TKKVFFKFLKTCAIFYQTCISELISKF---------------------QLDSYRPFFCKWTSSATVSSTISNDE------------- 
Saccharomyces cerevisiae   AVGDTYFQRAKIYLITG-----------------KFSLYFFELVRGALVRIPSKCALNNLKDFILTPDFP-------ERRRLMKKLAILVSKDLKGEKSFFEGQIVLQFLS--------- 

                                   730       740       750       760       770       780       790       800       810       820       830       840           
                           ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
Homo sapiens (A)           -------LAIRSKPLR-KTVKYALISAQRCMICQGDIARYREQASDTA-NYGKARSWYLKAQHIAPKNGRPYNQLALLAVY----------------------TRRKLDAVYYYMRSLAA 
Homo sapiens (B)           -------EPPPVTPQVGEGRKSRKFSRLSCLRRRRHPPKVGDDSDLSE-GFESDSSHDSARASEGSDSGS---------------------------------DKSLEGGGTAFDAETDS 
Caenorhabditis elegans     LCEQYIELPIGIQKFDSATQKTAIKSLSRHLISLGDLHRYKSLIDGSE-NYEISKSCYQKSSQLWPSTGHPYNQLGIVVYYSMLYRSARRARLVPVDVLSRQRQKRVIDEFFCLTRALAC 
Schizosaccharomyces pombe  -------MSSIPEASYSRNHMEALECVYNCFIYLGDMARYSSTCLKKRGAYDRALGFYDLAHRTLPGNGMHRNQIAVVWAS----------------------DECIVESIYWFSSALCS 
Saccharomyces cerevisiae   ------IVEHTLVPQSWNASRASNCWLLKEHLQMAALKYHSGNINVILENLAATMGSFDLMFTTRK-------------------------------------SKEQKNKLKYADLSERQ 

                                   850       860       870       880       890       900       910       920       930       940       950       960           
                           ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
Homo sapiens (A)           SNPILTAKESLMSLFEETKRKAEQMEKKQHEEFDLSPDQWRKGKKSTFRHVGDDTTRLEIWIHPSHPRSSQGTESGKDSEQENGLGSLSPSDLNKRFILSFLHAHGKLFTRIGMETFPAV 
Homo sapiens (B)           EMNSQESRSDLEDMEEEEGTRSPTLEPPRGRSEAPDSLNGPLGPS----EASIASNLQAMSTQMFQTKRCFRLAPTFSNLLLQPTTNPHTSASHRPCVNGDVDKPSEPASEEGSESEGSE 
Caenorhabditis elegans     SHPYEVAKDRLKQRIDAMRTKVAKYQPVLDKESGIVKEQGNVLRR--------LQRIRQIWIHPITETSQDGTGERIVDDVLVHFMEHSKAKLHRRAVSYLCDTFGMLVTKIGMDHFESV 
Schizosaccharomyces pombe  EDPPKSALLNLLKQLIAFYRRCFAVHFEFVSPMMILLFIIS-----------------DCCIHSLKEIQPFKCPSIMVKDLEN----------------------SLLQSNIRNVGYEKK 
Saccharomyces cerevisiae   VFFLDLSFDFIANIIDVVIKPSWQKNMEDFRYLAIIRLLMCWIKS-----------YRSILQYTHRHRKFCTSFALLLNDLIN----------------------SPLNCSGNIYSHRPK 

                                   970       980       990       1000      1010      1020      1030      1040      1050      1060      1070      1080          
                           ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
Homo sapiens (A)           AEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVHNSQLKDCFSEECRSVIQEQAAALGLAMFSLLVRRCTCLLKESAKAQLSSPEDQDDQDDIKVSSFVPDLKELLPSVKVWSDWMLG 
Homo sapiens (B)           SSGRSCRNERSIQEKLQVLMAEGLLPAVKVFLDWLRTN--------PDLIIVCAQSSQSLWNRLSVLLN--------------------------LLPAAGELQESGLALCPEVQDLLEG 
Caenorhabditis elegans     SERAFGLLYASLSKSETDFSADQLVKFSAMFIYAAQVN-----FDKSTPSTSKSQLHTAVRTIFTYFL--------------------------VLLEHISTHTTLLLPAANVIATWILH 
Schizosaccharomyces pombe  NLYYISSAFSNLLHCRYFNCNDRLRSFYYRFSSWLFHQ-----------TLACAKEVESERAPTSYLTS--------------------------CLPSIKVILARVLESSPAFG----- 
Saccharomyces cerevisiae   RSYLFREDIIFREFSCINFALTDFNDDYVYDSPDMINN-----------IIGCPTLTKVLSPKEECVLR---------------------------IRSIIFSGMKFLEKNDTGVIWN-- 

                                   1090      1100      1110      1120      1130      1140      1150      1160      1170      1180      1190      1200          
                           ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
Homo sapiens (A)           YPDTWNPPPTSLDLPSHVAVDVWSTLADFCNILTAVNQSEVPLYKDPDDDLTLLILEEDRLLSGFVPLLAAPQDPCYVEKTSDKVIAADCKRVTVLKYFLEALCGQEEPLLAFKGGKYVS 
Homo sapiens (B)           CELP--DLPSSLLLPEDMALRNLPPLRAAHRRFN--FDTDRPLLSTLEESVVRICCIRS--FGHFIARLQGSILQFNPEVGIFVSIAQSEQESLLQQAQAQFR----------------- 
Caenorhabditis elegans     ADT--EELLSYLEHLEPLSSTIISSFSNFP-----------PNLESEAENPENVTTPEAILLASFFKIYEPNPTPVRCSRSTN--ISQAVEKLKILGFSAE------------------- 
Schizosaccharomyces pombe  ----------------------------------------------------------------FIERNELEQLSYHFRICEKFFKESSENK---------------------------- 
Saccharomyces cerevisiae   -----------------------------------------------------------------ASKYKFDLISPNIKIKRQIALSEISSKIN-------------------------- 

                                   1210      1220      1230      1240      1250      1260      1270      1280      1290      1300      1310      1320          
                           ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
Homo sapiens (A)           VAPVPDTMGKEMGSQEGTRLEDEEEDVVIEDFEEDSEAEGSGGEDDIRELRAKKLALARKIAEQQRRQEKIQAVLEDHSQMRQMELEIRPLFLVPDTNGFIDHLASLARLLESRKYILVV 
Homo sapiens (B)           ----------------------------------MAQEEARRNR---------------LMRDMAQLRLQLEVSQLEGSLQQPKAQSAMSPYLVPDTQALCHHLPVIRQLATSGRFIVII 
Caenorhabditis elegans     ----------------------------------KSEKSGENGK--------------QKLGDGLEEPKSREQMIDEQRGLGKTTIVIHPEYLIPDTN---------------------- 
Schizosaccharomyces pombe  ------------------------------------------------------------MLNLFEDYNEFGLCKSFICLFKRLNEDIIGPKLNINPPD--------------------- 
Saccharomyces cerevisiae   -----------------------------------------------------------VKTQQERVVSSRKVEAKRDEQQRKRAGKIAVTELEKQFAN--------------------- 

                                   1330      1340      1350      1360      1370      1380      1390      1400      1410      1420      1430      1440          
                           ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
Homo sapiens (A)           PLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFLEQRFESRDSCLRALTSRGNELESIAFRSEDITG-QLGNNDDLILSCCLHYCKDKAKDFMPASKEEPIRLLREVVLLTDDRN 
Homo sapiens (B)           PRTVIDGLD-LLKKEHPGARDG-------------IRYLEAEFKKGNRYIRCQKEVGKSFERHKLKRQDADAWTLYKILDSCKQLTLAQGAGEEDPSGMVTIITGLPLDNPSVLSGPMQA 
Caenorhabditis elegans     --VLIGDLQ-LMKNLQAKQKTG--------------------------HLYTLTTTGKRLPTLSIVSEDLEGHEMTTNDDMILNSALRWSESLPGSTAPSAT----EISQKCVLITGDRG 
Schizosaccharomyces pombe  -----------------------------------------------------------YTTHPFSESIKRFYQISKILNLLLS------------------------------------ 
Saccharomyces cerevisiae   -------------------------------------------------------VRRTKKLSPLPEKDGVSSELVKHAASRGRKTITG-------------------PLSSDFLSYPDE 

                                   1450      1460      
                           ....|....|....|....|....|.
Homo sapiens (A)           LRVKALTRNVPVRDIPAFLTWAQVG- 
Homo sapiens (B)           ALQAAAHASVDIKNVLDFYKQWKEIG 
Caenorhabditis elegans     LTIKAIGNNFPCRGISNFTKWIINV- 
Schizosaccharomyces pombe  -------------------------- 
Saccharomyces cerevisiae   AIDADEDITVQVPDTPT---------