10        20        30        40        50        60        70        80        90       100       110       120                    
                                ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
                                ~~~~~~~~~~~|-NL--|~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~|---TruB~I---|~~~~~~~~~~~~
Homo sapiens                    MADAEVII-LPKKHKKKKERK---SLPEEDVAEIQHAEEFLIKPESKVAKLDTSQWPLLLKNFDKLNVRTTHYTPLACGSNPLKREIGDYIRTGFINLDKPSNPSSHEVVAWIRRILRVE 
Rattus norvegicus               MADAEAAMTFPKKHKKKKERK---PLPEADVAEIQHAEDFLIKPESKAAQLDTSQWPLLLKNFDRLNVRTTHYTPIPCGSNPLKREIGEYVRTGFINLDKPSNPSSHEVVAWIRRILRVE 
Mus musculus                    MADAEVI-TFPKKHKKKKDRK---PLQEDDVAEIQHAEEFLIKPESKVAQLDTSQWPLLLKNFDKLNVRTAHYTPLPCGSNPLKREIGDYIRTGFINLDKPSNPSSHEVVAWIRRILRVE 
Bos taurus                      MADAEVLI-LPKKHKKKKERK---SLPEEAVAEIQHAEEFLIKPESRVAQLDTSQWPLLLKNFDKLNVRTTHYTPLPCGSNPLKREIGDYIRTGFINLDKPSNPSSHEVVAWIRRILRVE 
Gallus gallus                   MADGDG---SSVKKRRKKDKR---SLPDEDVADIQHTEEFLIKPESRVAQLDTSQWPLLLKNFDKLNVLTTHYTPLPSGANPLKREISDYVRSGFINLDKPSNPSSHEVVAWIRRILRVE 
Danio rerio                     MADTES-----KKEKKRKSKK----ISDEEVGDIQESGDFLIKPESKVASLDTSQWPLLLKNFDKLNIRTAHYTPLPHGSNPLKRGIHDYVRSGFINLDKPANPSSHEVVAWIKRILRVE 
Drosophila melanogaster         MADVEV-----RKEKKKKKIKEEP-LDGDDIGTLQKQGNFQIKPSSKIAELDTSQWPLLLKNFDKLNIRSNHYTPLAHGSSPLNRDIKEYMKTGFINLDKPSNPSSHEVVAWIKKILKVE 
Anopheles gambiae               MEVDI-PTSPIKKEKKKKKIKQEPDTEIENLGEIQKSGDFQLKPSSAIASLDTSKWPLLLKNFDRLNVRTNHYTPLPFGSSPLNRKINDYVSAGFINLDKPSNPSSHEVVAWIKRILKVN 
Aedes aegypti                   MSDYEMGSPTIKKEKKKKKIKQEPGAEIENLGEIQKSGNFQIQPSAAIAKLDTSQWPLLLKNFDRLNVRTNHYTPLPFGSSPLNRKIKDYVTSGFINLDKPSNPSSHEVVAWIKKILKVD 
Culex pipiens quinquefasciatus  MG-----SPHIKKEKKKKKIKQEPGVEVENLGEIQKSGDFQIKPSEAIAKLETSKWPLLLKNFDRLNVRTNHYTPLPFGSSPLNRKIKDYVTSGFINLDKPSNPSSHEVVAWIKKILKVE 
Caenorhabditis elegans          MG---------KKDKRSK-------LEGDDLAEAQQKGSFQLPSSNETAKLDASQWPLLLKNYDKLNVRTNHYTPHVEGVSPLKRDIKNYISSGFFNLDKPSNPSSHEVVSWIKRILRCE 
Schizosaccharomyces pombe       MTD-----------------------------THPGVDFMIKPEATSASKIDTAEWPLLLKNFDKLLVRTGHYTPIPCGNNPLKRPIAEYVSSGVINLDKPANPSSHEVVAWVKKILRVE 
Saccharomyces cerevisiae        MSK----------------------------------EDFVIKPEAAGASTDTSEWPLLLKNFDKLLVRSGHYTPIPAGSSPLKRDLKSYISSGVINLDKPSNPSSHEVVAWIKRILRCE 
Kluyveromyces lactis            MS-----------------------------------DEFVIKPESVSPSSNTSEWPLLLKDYDKLLVRSGHYTPIPAGASPLKRDLKSYISSGVINLDKPSNPSSHEVVAWIKRILRCE 
Ashbya gossypii                 MS-----------------------------------EEHMIKPENVAPSADTSEWPLLLKNYDKLLVRSGHYTPIPAGASPLKRDLKSYVSSGVINLDKPSNPSSHEVVAWIKRILRCE 
Lodderomyces elongisporus       MSK----------------------------------EDFQIKPEAVTPANNTSDWPLLLKNYDKLLVRSGHYTPIPAGSSPNNRDLKSYVSSGVINLDKPSNPSSHEVVAWIKRILRVE 
Pichia stipitis                 MS-----------------------------------DEYFIKPEAVSPSNDTSEWPLLLKNFDKLLVRSGHYTPIPSGSSPLKRDIKSYISSGVINLDKPSNPSSHEVVAWIKRILRSE 
Pichia guilliermondii           MAPHDAMRIF------------LNTIIVVFIFPVAMSDEYMIKPESIAPSNDTSEWPLLLKNFDKLLVRSGHYTPIPAGSSPLKRDLKSYVSSGVINLDKPSNPSSHEVVAWIKRILRTE 
Zygosaccharomyces rouxii        MSK-----------------------------------DFVIKPDTSGPTPDTAEWPLLLKDYDKLLMRSGHYTPIPAGSSPGKRDIKSYVNSGVINLDKPSNPSSHEVVAWIKRILRCE 
Aspergillus fumigatus           MAV----------------------------SVTKEEMDYTIKPEAGASNISTEDWPLLLKNYDKLMVRTGHFTPIPAGCSPLKRDLKSYISSGVINLDKPSNPSSHEVVAWMKRILRAE 
Aspergillus clavatus            MAV----------------------------ALAKEEMDYTIKPEAGASNISTEEWPLLLKNYDKLLVRTGHFTPIPAGCSPLKRDLKSYVSSGVINLDKPSNPSSHEVVAWMKRILRAE 
Aspergillus nidulans            M---------------------------------AKEVDYTIKPEATASNINTEDWPLLLKNYDKLMVRTGHFTPIPAGSSPLKRDLKSYINSGVINLDKPSNPSSHEVVAWMKRILRAE 
Chaetomium globosum             M----------------------SDSKALVKKGEDNEVEYMIKPQTLVPTLNTSDWPLLLKNYDKMLVRSGHFTPIPNGSSPYKRDIKSYVSSGVINLDKPSNPSSHEVVAWLKRMLRVE 
Magnaporthe grisea              MGG-------------------NKDALALARRDEEVDEEFSIKPEQVTPALDTSSWPLLLKNYDKLHIRTGHFTPIPNGSTPLRRDIKSYISSGVINLDKPSNPSSHEVVAWIKRILRCE 
Neurospora crassa               MG---------------------------------AETEHVIKPQATEPAVDTSEWPLLLKNYSNLLVRTGHFTPIPAGSSPSKRDIKSYVSSGVINLDKPSNPSSHEVVAWIKRMLRVE 
Botryotinia fuckeliana          MALV--------------------------STKKEQEVDYTIKPEALTPAVDTSSWPLLLKNYNNLLVRTGHFTPIPNGCTPLKRDLKSYISSGVINLDKPSNPSSHEVVAWVKRMLRVE 
Pyrenophora tritici-repentis    MALV-----------------------------QTDPDAYVIKPAAAAPAIDTSDWPLLLKNYSDLLVRTSHYTPIPNGCAPLSRDLKSYISSGVINLDKPSNPSSHEVVSWIKRMLRVE 
Neosartorya fischeri            MAV----------------------------SVAKEEMDYTIKPEAGASNISTEEWPLLLKNYDKLMVRTGHFTPIPAGCSPLKRDLKSYISSGVINLDKPSNPSSHEVVAWMKRILRAE 
Coccidioides immitis            MAA------------------------------SKSDMDFSIKPEAATPPIPTSEWPLLLKNYDKLLVRTGHFTPIPAGCTPLKRDLKSYISSGVINLDKPSNPSSHEVVAWMKRILRVE 
Dictyostelium discoideum        MTT--------------------DKKSKSKSSEKSTQEVEQVIKPEKTPILDTSKWPLLLKNYDQLSVRTGHYTPIPNGHSPLKRPIKEYVKYGIINLDKPSNPSSHEVVAWIRTILRVT 
Arabidopsis thaliana            MAEVDI-------------SHSKKKKQDKTENDAADTGDYMIKPQSFTPAIDTSQWPILLKNYDRLNVRTGHYTPISAGHSPLKRPLQEYIRYGVINLDKPANPSSHEVVAWIKRILRVE 
Chlamydomonas reinhardtii       MSV----------------------------GEAQQRTDFLIQPEKTVPKLDTSKWPLLLKNYDKLNVRTGHYTPIPAGSTPLKRPLKEYLSYGCINLDKPANPSSHEVVAWVKRMLRVE 
Cryptosporidium parvum          SSM---------------------GKRKELEEMSDGKIETVIKPESKSQPIDTSNWPLLLKNYSKLNVRTGHYTPLPYGNSPLNRNLADYLSYGIINLDKPANPSSHEVVAWIKKILRCE 
Euglena gracilis                MAKA----------------------------QWENDFSIPTESGEKGAALDSSEWPLLLKNYDKLNVRSAHYTPIPQGHTPLKRPIKAYLQYGCLNLDKPSNPSSHEVVSWLKRILKVE 
Methanocaldococcus jannaschii   MILLE------------------------------------------------KTQEKKINDKEELIVKEEVETNWDYGCNPYERKIEDLIKYGVVVVDKPRGPTSHEVSTWVKKILNLD 

                                        130       140       150       160       170       180       190       200       210       220       230       240           
                                ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
                                ~~~~|---TruB~II--|~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
Homo sapiens                    KTGHSGTLDPKVTGCLIVCIERATRLVKSQQSAGKEYVGIVRLHNAIEG-GTQLSRALETLTGALFQRPPLIAAVKRQLRVRTIYESKMIEYDPERRLGIFWVSCEAGTYIRTLCVHLGL 
Rattus norvegicus               KTGHSGTLDPKVTGCLIVCIERATRLVKSQQSAGKEYVGVVRLHNAIEG-TAQLSRALETLTGALFQRPPLIAAVKRQLRVRTIYESRVVEYDPERRLGVFWVSCEAGTYIRTLCVHLGL 
Mus musculus                    KTGHSGTLDPKVTGCLIVCIERATRLVKSQQSAGKEYVGIVRLHNAIEG-GTQLSRALETLTGALFQRPPLIAAVKRQLRVRTIYESKMIEYDPERRLGIFWVSCEAGTYIRTLCVHLGL 
Bos taurus                      KTGHSGTLDPKVTGCLIVCIERATRLVKSQQSAGKEYVGIVRLHNAIEG-GTQLSRALETLTGALFQRPPLIAAVKRQLRVRTIYESKMIEYDPERRLGIFWVSCEAGTYIRTLCVHLGL 
Gallus gallus                   KTGHSGTLDPKVTGCLIVCIERATRLVKSQQSAGKEYVGIVRLHNAIES-EAQLARAIETLTGALFQRPPLIAAVKRQLRVRTIYESKLVEYDPERRLGIFWVSCEAGTYIRTLCVHLGL 
Danio rerio                     KTGHSGTLDPKVTGCLIVYVERATRLVKSQQSAGKEYVGIVRLHNALEN-EHQLARALECLTGALFQRPPLIAAVKRQLRVRTIYESKLIEYDPERRLGIFWVSCEAGTYIRTLCVHLGL 
Drosophila melanogaster         KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQSAGKEYVAIFKLHGAVES-VAKVRQGLEKLRGALFQRPPLISAVKRQLRVRTVYDSKLLDYDETRNMGVFWVSCEAGSYIRTMCVHLGL 
Anopheles gambiae               KTGHSGTLDPKVTGCLIVCINRATRLVKSQQSAGKEYVAVFKLHSAVEK-IAKVTQGLEKLRGALFQRPPLISAVKRQLRVRTVYDSKLLDYNDQRNIGVFWVSCEAGSYIRTMCVHLGL 
Aedes aegypti                   KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQSAGKEYVAVFKLHSAVES-VAKVNQGLEKLRGALFQRPPLISAVKRQLRVRTVYDSKLLDYDDQRNMGVFWVSCEAGSYIRTMCVHLGL 
Culex pipiens quinquefasciatus  KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQSAGKEYVAVFKLHSAVES-VAKVNQGLEKLRGALFQRPPLISAVKRQLRVRTVYDSKLLDYDDQRNMGVFWVSCEAGSYIRTMCVHLGL 
Caenorhabditis elegans          KTGHSGTLDPKVSGCLIVCIDRTTRLAKSQQGAGKEYICIFKLHEEVED-DRKVKQALEKLTGALFQRPPLISAVKRQLRIRTVYENKFIEYDPAQQMGIFNCICESGTYVRTICVHLGL 
Schizosaccharomyces pombe       KTGHSGTLDPKVTGCLIICNDRATRLVKSQQSAGKEYVCVLRLHDSVEG-ERNVASAIETLTGALFQRPPLISAVKRQLRIRSIYESKLIEFDNERNLAVFWASCEAGTYMRTLCVHLGL 
Saccharomyces cerevisiae        KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCIVRLHDALKD-EKDLGRSLENLTGALFQRPPLISAVKRQLRVRTIYESNLIEFDNKRNLGVFWASCEAGTYMRTLCVHLGM 
Kluyveromyces lactis            KTGHSGTLDPKVTGCLIVCVDRATRLVKSQQGAGKEYVCIVRLHDALKD-EKELGRGLENLTGALFQRPPLISAVKRQLRVRTIYDSNLIEFDNKRNLGVFWASCEAGTYMRTLCVHLGM 
Ashbya gossypii                 KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCIVRLHDALKD-EKDLGRELENLTGALFQRPPLISAVKRQLRVRTIYDSKLIEFDNKRNLGVFWASCEAGTYMRTLCVHLGM 
Lodderomyces elongisporus       KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCIVRLHDQLEE-PKELNRALENLTGALFQRPPLISAVKRQLRVRTVYDSKLIEFDNKRGLGVFWASCEAGTYMRTLCVHLGM 
Pichia stipitis                 KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCIVRLHEELKD-AKDLGRSLENLTGALFQRPPLISAVKRQLRVRTIYDSNLIEFDNKRGLGVFWASCEAGTYMRTLCVHLGM 
Pichia guilliermondii           KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCIVRLHDELKD-AKDMGRSLENLTGALFQRPPLISAVKRQLRVRTIYDSNLIEFDNKRGLGVFWASCEAGTYMRTLCVHLGM 
Zygosaccharomyces rouxii        KTGHSGTLDPKVTGCLIVCVDRATRLVKSQQGAGKEYVCIVRLHDALKD-EKDLGRSLESLTGALFQRPPLISAVKRQLRVRTIYDSNLIEFDNKRNLGVFWASCEAGTYMRTLCVHLGM 
Aspergillus fumigatus           KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCVIRLHDKIPGGEAQFKRALETLTGALFQRPPLISAVKRQLRIRTIHESKLYEFDNDRHLGVFWVSCEAGTYIRTLCVHLGL 
Aspergillus clavatus            KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCVIRLHDKIPGGEAQFKRALETLTGALFQRPPLISAVKRQLRIRTIHESKLYEFDNERHLGVFWVSCEAGTYIRTLCVHLGL 
Aspergillus nidulans            KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCVIRLHDKIPGGEAQFKRALETLTGALFQRPPLISAVKRQLRIRTIHESKLYEFDNERHLGVFWVSCEAGTYIRTLCVHLGL 
Chaetomium globosum             KTGHSGTLDPKVTGCLIVCIDRATRLVKAQQGAGKEYVAVVRFHDTIPGGEPAFAKALETLTGALFQRPPLISAVKRQLRIRTIHESKLIEFDNDRHLGVFWVSCEAGTYIRTLCVHLGL 
Magnaporthe grisea              KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCVIRLHDKVPGGEPEFARALETLTGALFQRPPLISAVKRQLRIRTIHESKLIEFDNDRHLGVFWVSCEAGTYIRTLCVHLGL 
Neurospora crassa               KTGHSGTLDPKVTGCLIVCVDRATRLVKAQQGAGKEYVCVIRFHDSVPGGEAAFASALETLTGALFQRPPLISAVKRQLRIRSIYESKLIEFDNDRHLGVFWVSCEAGTYIRTLCVHLGL 
Botryotinia fuckeliana          KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCVIRLHDKLPGGEAQFARALETLTGALFQRPPLISAVKRQLRIRTIHESKLYEFDNDRHLGVFWVSCEAGTYIRTLCVHLGL 
Pyrenophora tritici-repentis    KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCVIRLHDKLPGGEAQFARALETLTGALFQRPPLISAVKRQLRIRTIHESKLYEFDNERQLGVFWVSCEAGTYIRTLCVHLGL 
Neosartorya fischeri            KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCVIRLHDKIPGGEAQFKRALETLTGALFQRPPLISAVKRQLRIRTIHESKLYEFDNDRHLGVFWVSCEAGTYIRTLCVHLGL 
Coccidioides immitis            KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCVIRLHDKIPGGEAQFARALETLTGALFQRPPLISAVKRQLRIRTIHESKLYEFDNDRHLGVFWVSCEAGTYIRTLCVHLGL 
Dictyostelium discoideum        KTGHSGTLDPKVTGCLIVCIERATRLVKSQQGAGKEYIGIVRLHGAIEG-TTELSKAVDTLTGALFQRPPQKSAVKKRLRVRTIHNSKLLEFDPERNLGLIWVDCEAGTYIRTLCVHIGL 
Arabidopsis thaliana            KTGHSGTLDPKVTGNLIVCIDRATRLVKSQQGAGKEYVCVARLHSAVP-DVAKVARALESLTGAVFQRPPLISAVKRQLRIRTIYESKLLEYDADRHLVVFWVSCEAGTYIRTMCVHLGL 
Chlamydomonas reinhardtii       KTGHSGTLDPKVTGNLIVCIDRATRLVKAQQAAGKEYVCIARFHGKVEGGTAAVNKALETLTGALFQRPPLISAVKRQLRVRTIYQAKLYEYDEERHLAVFWISCEAGTYVRTLCVHLGL 
Cryptosporidium parvum          KTGHSGTLDPKVTGCLLVCLNRATRLVKSQQSAGKEYVCIVRFHSSVGG-KSAVSRCLETLTGALFQRPPVISAVKRQLRVRSIYDSKLLDYDEKRNLAVFWAKCEAGTYIRTMCVHMGL 
Euglena gracilis                KTGHAGTLDPKVTGSLLICIERATRLVKSQQNAGKEYVGVLRLHDALKD-EAQLLKALEDLTGAVFQRPPVVAAVKRTLRIRTIYESKLLDFDNDRHLAVFWISCEAGTYVRTLCVHLGF 
Methanocaldococcus jannaschii   KAGHGGTLDPKVTGVLPVALERATKTIPMWHIPPKEYVCLMHLHRDASE--EDILRVFKEFTGRIYQRPPLKAAVKRRLRIRKIHELELLDKDGKD--VLFRVKCQSGTYIRKLCEDIGE 

                                        250       260       270       280       290       300       310       320       330       340       350       360           
                                ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
                                ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~|---------------------------------------PUA~domain-------
Homo sapiens                    LLGVGGQMQELRRVRSGVMSEK--DHMVTMHDVLDAQWLYDNHKDESYLRRVVYPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGVLRY---------EDGIEVNQEIVVITTKGEAIC 
Rattus norvegicus               LLGVGGQMQELRRVRSGVVGER--DHMVTMHDVLDAQYLYDHHRDESYLRRVVFPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGLLRY---------EDGIEVNQEVVVITTKGEAVC 
Mus musculus                    LLGVGGQMQELRRVRSGVMSEK--DHMVTMHDVLDAQWLYDNHKDESYLRRVVYPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGLLRY---------EDGIEVNQEIVVITTKGEAIC 
Bos taurus                      LLGVGGQMQELRRVRSGVMSEK--DHMVTMHDVLDAQWLYDNHKDESYLRRVVYPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGVLRY---------EDGIEVNQEIVVITTKGEAIC 
Gallus gallus                   LLGVGGQMQELRRVRSGILGEM--DNMVTMHDVLDAQWQYDNNKDDSYLRRVILPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGVLRY---------EDGIELKQEIVVITTKGEAIC 
Danio rerio                     LLGVGGQMQELRRVRSGVLGEK--DNLVTMHDVLDAQWQFDHNKDETYLRRVIFPLEKLLISHKRIVMKDSAVNAICYGAKIMLPGVLRY---------EDGIEVNQDIVVITTKGEAIC 
Drosophila melanogaster         VLGVGGQMLELRRVRSGIQSER--DGMVTMHDVLDAMWLYENHKDESMLRRVIKPLEGLLVNHKRIIMKDSSVNAVCYGAKITLPGVLRY---------EDGIEIDQEIVICTTKGEAIC 
Anopheles gambiae               VLGVGGQMLELRRVRSGIQSEK--DGMVTMHDVLDAQYLYENHKDESMLRRVIKPLEGLLVGHKRIIMKDSSVNAVCYGAKILLPGVLRY---------EDGIEIDQEIVIVTTKGEAIA 
Aedes aegypti                   VTGVGGQMLELRRVRSGIQSEK--DGMVTMHDVLDAQYLYDNHKDETMLRRVIKPLEGLLVGHKRIIMKDSSVNAVCYGAKIMLPGVLRY---------EDGIEMDQEIVIVTTKGEAVA 
Culex pipiens quinquefasciatus  VTGVGGQMLELRRVRSGIQSEK--DGMVTMHDVLDAQYLYENHKDESMLRRVIKPLEGLLIGHKRIIMKDSSVNAVCYGAKIMIPGVLRY---------EDGIEVDQEIVIVTTKGEAIA 
Caenorhabditis elegans          ILGCGGQMQELRRNRSGICDEN--ENMVTMHDVLDAQYLLDTQKDESYMRHIVRPLEALLTQHKRVVVKDSCINAICYGAKILIPGILRY---------DDDIEVGKEIVIMSTKGEAIC 
Schizosaccharomyces pombe       LLGVGGHMQELRRVRSGCLSEN--DDIVTMHDVLDAQWIYDNTRDESYLRRVIRPLESLLVGYKRIVVKDSAVNAICYGAKLMIPGLLRY---------EAGIEVNEEIVLITTKGEAIA 
Saccharomyces cerevisiae        LLGVGGHMQELRRVRSGALSEN--DNMVTLHDVMDAQWVYDNTRDESYLRSIIQPLETLLVGYKRIVVKDSAVNAVCYGAKLMIPGLLRY---------EEGIELYDEIVLITTKGEAIA 
Kluyveromyces lactis            LLGVGGHMQELRRVRSGALSEN--DNLVTLHDVMDAQWVYDNTRDESYLRKIIQPLETLLVGYKRIVVKDSAVNAVCYGAKLMIPGLLRY---------EEGIELYDEVVLITTKGEAIA 
Ashbya gossypii                 LLGVGGHMQELRRVRSGALDEN--DNMVTLHDVLDAQWVYDNTRDESYLRKIIQPLETLLVGYKRIVVKDSAVNAVCYGAKLMIPGLLRY---------EEGIELYDEVVLITTKGEAIA 
Lodderomyces elongisporus       LLGVGGHMQELRRVRSGAMSES--DNLVTLHDVLDAQYVYDNTRDESYLRKIIQPLETLLVGYKRLVVKDSAVNSVCYGAKLMLPGLLRY---------ESGIELYDEVVLITTKGEAIA 
Pichia stipitis                 LLGVGGHMQELRRVRSGALGEN--DNLVTLHDVLDAQYVYDNTRDESYLRKIIQPLETLLVGYKRIVVKDSAVNSVCYGAKLMIPGLLRY---------EEGIELYDEVVLMTTKGEAIA 
Pichia guilliermondii           LLGVGGHMQELRRVRSGALAEN--DNLVTLHDVLDAQYVYDNTRDESYLRKIIQPLETLLVGYKRIVVKDSAVNSVCYGAKLMIPGLLRY---------EEGIELYDEVVLITTKGEAIA 
Zygosaccharomyces rouxii        LLGVGGHMQELRRVRSGALSEN--DNLVTLHDILDAQWVYDNTRDESYLRRVIQPLETLLVGYKRIVVKDSAVNAVCYGAKLMIPGLLRY---------EDGIELYDEVVLITTKGEAIA 
Aspergillus fumigatus           LLGVGAHMQELRRVRSGAMDEN--NGLVTLHDVLDAQWMYDNQRDESYLRRVIQPLESLLTTYKRIVVKDSAVNAVCYGAKLMIPGLLRF---------EAGIEVNEEVVLMTTKGEAIA 
Aspergillus clavatus            LLGVGAHMQELRRVRSGAMDEN--NGLVTLHDVLDAQWMYDNQRDESYLRRVISPLESLLTTYKRIVVKDSAVNAVCYGAKLMIPGLLRF---------EAGIDVNEEVVLMTTKGEAIA 
Aspergillus nidulans            LLGVGAHMQELRRVRSGAMSEN--EGMVTLHDVLDAQWLYDNQRDESYLRKVIKPLESLLTTYKRIVVKDSAVNAVCYGAKLMIPGLLRFGQKSLTWGLEAGIELGEEVVLMTTKGEAIA 
Chaetomium globosum             LLGVGAHMQELRRVRSGVMSED-NGSLVTLHDVLDAQWQYDNGGDESYLRKVIQPLETLLCTYKRLVVKDSAVNAVCYGAKLMLPGLLRY---------DAGIDAHEEVVLMTTKGEAIA 
Magnaporthe grisea              MLGVGAHMQELRRVRSGAMDET--KDLHTLHDVLDAQWLMDNTRDESYLRKVIQPLETLLTTYKRLVVKDSAVNAVCYGAKLMLPGLLRY---------EADIELHEEVVLMTTKGEAIA 
Neurospora crassa               LLGVGAHMQELRRVRSGIMSED-NGSMVTLHDVLDAQWQFDNGGDETALRKVIQPLETLLTTYKRIVVKDSAVNAVCYGAKLMLPGLLRF---------EKGIETHEEVVLMTTKGEAIA 
Botryotinia fuckeliana          LLGVGAHMQELRRVRSGAMDET--KDMVTLHDVLDAQWMQDNARDEAYLRKVIQPLETLLTTYKRIVVKDSAVNAVCYGAKLMIPGLLRY---------EADIEVHEEVVLMTTKGEAIA 
Pyrenophora tritici-repentis    LLGVGAHMQELRRVRSGAMDET--KDLVTLHDVLDAQWLHDNNRDEAYLRKVIAPLESLLMSYKRIVVKDSSVNAICYGAKLMLPGLLRF---------EKGIEIHEEVVLMTTKGEAIA 
Neosartorya fischeri            LLGVGAHMQELRRVRSGAMDEN--NGLVTLHDVLDAQWMYDNQRDESYLRRVIRPLESLLTTYKRIVVKDSAVNAVCYGAKLMIPGLLRF---------EAGIDVNEEVVLMTTKGEAIA 
Coccidioides immitis            LLGVGAHMQELRRVRSGAMDEQ--DGMVTLHDVLDAQWMMDNNRDESYLRRVVRPLETLLTTYKRVVVKDSAVNAVCYGAKLMIPGLLRF---------EAGIEVHEEVVLMTTKGEAIA 
Dictyostelium discoideum        LMGVGGHMQELRRVRSGIMSEK--KGQVTMHDVKDAQYEYDNSKDESYLRRVIQPLEAILTNYKRIVVKDSAINAICYGAKLMIPGLLRY---------EQDIESNEEVVLITTKGEAIA 
Arabidopsis thaliana            LLGVGGHMQELRRVRSGILGEN--NNMVTMHDVMDAQFVYDNSRDESYLRRVIMPLEMILTSYKRLVVKDSAVNAICYGAKLMIPGLLRF---------ENDIDVGTEVVLMTTKGEAIA 
Chlamydomonas reinhardtii       LLGVGGHMQELRRVRSGIMGEAPSNNMVTMHDVLDAQWLYDNFKDESYLRRAVMPLEVLLTSFKRLVVKDSAVNAICYGAKLMIPGLLRF---------ESGVEVDDEVVLMTTKGEAVA 
Cryptosporidium parvum          LLGVGAHMQELRRVRSGCLSEN--DNMVTMHDILDAQYMLDNYRDESYLRRIISPLELLLTDLPRIVVKDSCVNAICYGAKLMIPGVLRF---------DNGIDVGTEVVMMTTKGEAIA 
Euglena gracilis                VLGTAGHMAELRRTRTGHLGEN--DGMVTMHDVLDAMHLYDQEGDESYLRRTVMPCELLLTAYKRVVVKDTAVNAICYGAKLMIPGLLRF---------ENGIEVNEVIVLMTTKGEAIA 
Methanocaldococcus jannaschii   ALGTSAHMQELRRTKSGCFEEK---DAVYLQDLLDAYVFWKEDGDEEELRRVIKPMEYGLRHLKKVVVKDSAVDAICHGADVYVRGIAKL---------SKGIGKGETVLVETLKGEAVA 

                                        370       380       390       400       410       420       430       440       450       460       470       480           
                                ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
                                -------------------------|~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
Homo sapiens                    MAIALMTTAVISTCDHGIVAKIKRVIMERDTYPRKWGLGPKASQKKLMIKQGLLDKHGKPTDSTPATWKQEY-------VDYSESAKKEVVAEVVKAPQVVAEAAKTA------------ 
Rattus norvegicus               VAIALMTTAVISTCDHGVVAKIKRVIMERDTYPRKWGLGPKASQKKQLIKQGLLDKHGRPTDGTPASWTRDY-------VDYSDSSKKATAAEATPGPGVTADAASIV------------ 
Mus musculus                    MAIALMTTAVISTCDHGIVAKIKRVIMERDTYPRKWGLGPKASQKKMMIKQGLLDKHGKPTDNTPATWKQDY-------IDYSDSGKNTLVTEAVQAPQLAAEAVNVI------------ 
Bos taurus                      MAIALMTTAVISTCDHGIVAKIKRVIMERDTYPRKWGLGPKASQKKLMIKQGLLDKHGKPTDSTPATWMQEY-------VDYSNSAKKDVPPKAVKATPVVAEVVKTP------------ 
Gallus gallus                   LAIALMTTAVISTCDHGVVAKIKRVIMERDTYPRKWGLGPKASQKKMMIQKGLLDKHGKPNECTPDSWKKEY-------VDYRESSKK----EAAKVPQAVSEVERAP------------ 
Danio rerio                     TAVALMTTAVISTCDHGVVAKIKRVIMERDTYPRKWGLGPKASQKKMMIQKGLLDKHGKPNNSTPSDWKEGY-------VDYSTTKVK----KGG---------EASA------------ 
Drosophila melanogaster         LAIALMTTATMASCDHGVVAKIKRVIMERDTYPRKWGLGPKASAKKALIAAGKLDKFGRPNENTPKEWLTGY-------VDYNAKKPAAQEVSPTNGSSEP-------S----------- 
Anopheles gambiae               LGIALMTTATMAGCDHGVVAKIKRVIMERDTYPRKWGLGPKASMKKQLIASGKLDKYGKPNENTPKDWLNSY-------SDFNR---SAKQANGNGTSADD---EFAGG----------- 
Aedes aegypti                   LAIALMTTATMASCDHGVCAKIKRVIMERDTYPRKWGLGPKASMKKQLIASGKLDKYGKPNDKTPKEWLTGY-------VDFNKPAAPGKDTNGNGAAAAEGEDEFAGG----------- 
Culex pipiens quinquefasciatus  LGVALMTTATMASCDHGVCAKIKRVIMERDLYPRKWGLGPKASMKKQLIASGKLDKFGKPNDKTPKEWLTGY-------TDYNK----AKPSNGNQVAAEE-DDEVVGG----------- 
Caenorhabditis elegans          IAIAQMNTSTIASVDHGVVAKSKRVIMERDVYGRKWGLGPVASKKKQMVKDGLLDKFGKPNDTTPKSWAKEY-------VQTST------------------------------------ 
Schizosaccharomyces pombe       VGIAQMSTVELSTCDHGVVAKVKRCIMERDVYPRRWGLGPQSMKKKTLKKEGKLDKYGRPNENTPADWSKSY-------IDYS--DPNAEVAKPAPVVAPAAPTVEAEVNGVEDS----- 
Saccharomyces cerevisiae        VAIAQMSTVDLASCDHGVVASVKRCIMERDLYPRRWGLGPVAQKKKQMKADGKLDKYGRVNENTPEQWKKEY-------VPLDNAEQSTSSSQETKETEEEPKKAKEDS----------- 
Kluyveromyces lactis            VAIAQMSTVDLATCDHGVVAKVKRCIMERDLYPRRWGLGPIAQKKKQMKADGKLDKYGRANENTPETWKKTY-------VSLENAEPTTAPASKSEE-KPLIKEVE-------------- 
Ashbya gossypii                 VAIAQMSTVDLATCDHGVVAKVKRCIMERDLYPRRWGLGPVAQKKKQLKADGKLDKYGRVNENTPEDWKKTY-------VSHE-PSADAAAEVAPVKSEPLIEEVS-------------- 
Lodderomyces elongisporus       IGIAQMTTVDLQSCDHGVVAKVKRCIMERDTYPRRWGLGPVAQKKKQLKADGKLDKYGRVNDETPETWKKEY-------KDLD--EAPAPAIPESKLVAPAPQ-LP-------------- 
Pichia stipitis                 IGIAQMTTVDLQGCDHGVVAKVKRCIMERDTYPRRWGLGPVAQKKKQMKADGKLDKFGRANENTPETWKQEY-------KDHD--EEPAPAVPASKLVAPEVQ-LP-------------- 
Pichia guilliermondii           IGIAQMTTVDLQSCDHGIVAKVKRCIMERDTYPRRWGLGPVAQKKKQLKADGKLDKYGRTNENTPESWKAEY-------KDHD--ETPAPPVPEAKLAAPEIQ-LP-------------- 
Zygosaccharomyces rouxii        VAIAQMSTVDLATCDHGVVAKVKRCIMERDLYPRRWGLGPVAQKKKQMKVDGKLDKYGRVNESTPEDWKKSY-------VPLDNAEAPAARESAPKESAPLVQEVD-------------- 
Aspergillus fumigatus           IGIAQMSTVELSTCDHGVVAKVKRCIMERDLYPRRWGLGPVALEKKKLKSAGKLDKYGRANEDTPAKWKTEY-------KDYSAPEEASA-HAASESTAKEDVAAALTT--------EQD 
Aspergillus clavatus            IGIAQMSTVELSTCDHGVVAKVKRCIMERDLYPRRWGMGPVALEKKKLKSAGKLDKYGRTNEATPAKWKTEY-------KDYNAPEDAAA-QPATETNGTEEAAAAPAA--------EQA 
Aspergillus nidulans            IGIAQMSTVELSTCDHGVVAKVKRCIMERDLYPRRWGLGPVALEKKKLKSSGKLDKYGRANEATPAKWKSEY-------KDYSAPDGDSS-QQAVDVVAKEEASP------------KEE 
Chaetomium globosum             IGIAQMSTVEMSTCDHGVVAKVKRCIMERDLYPRRWGLGPVAMEKKKLKADGKLDKFGRTNEATPAKWQQGY-------TDYGAA---DAAAAAAASAAAAPLEA--------------A 
Magnaporthe grisea              IGIAQMSTVEISSCDHGVVAKVKRCIMERDLYPRRWGLGPVAGEKKKLKADGKLDKFGRPNEATPSRWTQNY-------KDYSAPAPDAAAPAAD--EAAAATESP-------------A 
Neurospora crassa               IGIAQMNGVEMLSCDHGVVAKVKRCIMERDLYPRRWGLGPVALEKKKLKSDGKLDKFGRPNAETPAKWTEGY-------KDFSAAAESEAAAAAAPAAEAAKVEI--------------A 
Botryotinia fuckeliana          LGIAQMSTVELSSCDHGVVAKVKRCIMERDLYPRRWGMGPVAIEKKKMKTEGKLDKYGRPNEATPAKWNNEY-------KDFNAPPEDGAIAIHPKPEVVASAVAP-------------A 
Pyrenophora tritici-repentis    LAYAQMSAVEMSSCDHGVVAKIKRVIMERDLYPRRWGMGPVATEKKKMKEAGTLDKFGRPNDKTPAKWNTEY-------KDFNRNDVDGASAPVAQTTSTAEVLAAPAI--------PAT 
Neosartorya fischeri            IGIAQMSTVELSTCDHGVVAKVKRCIMERDLYPRRWGLGPVALEKKKLKSAGKLDKYGRANEDTPAKWKTEY-------KDYSAPEEASA-QAAPGSTAKEDVAAALTT--------EQD 
Coccidioides immitis            LGIAQMSTVEMSTCDHGVVAKVKRCIMERDLYPRRWGMGPVALEKKKMKADGKLDKFGRPNASTPAKWQAEY-------KDYSASADAAAPQPATEATPATPAQAPAAS--------PEE 
Dictyostelium discoideum        IGIAQMTTASMATCDHGVVATIKRVIMDRDVYPVRWGLGPKAKVKKEMIKDGKLDKFGKPNEKTPSDWTNTY-------TYYTGQVATTTTTSPVESMNVDTPKKATASVA--------V 
Arabidopsis thaliana            VGIAEMTTSVMATCDHGVVAKIKRVVMDRDTYPRKWGLGPRASMKKKLIADGKLDKHGKPNEKTPVEWSRNV-------VLPTGGDAIIAGAAAAPEEIKADAENGEAGEARKRKHDDSS 
Chlamydomonas reinhardtii       VGIAQMTTGVMATVDHGCVAKIKRVIMERDTYPRRWGLGPYAQIKKKLITEGKLDKHGRPNENTPKEYLR---------SLP---DFVANGGASAAAAAPAAAT---------------- 
Cryptosporidium parvum          IGVAQMTTAVIASVDHGVVAIIKRVIMERDTYDMRWGHGPRASEKKKLILGGKLDKHGKPNEQTPESWLKYEGYIPKLTGDHDDQNDEGKDITGSGLESESNSNIESSS-SKKRKEKKET 
Euglena gracilis                LGIALMTTADMGTCDHGIVAKIKRVVMDRDTYPRRWGLGPVALKKKEMIERGHLDKHGRRTEATPNSWW--Y-------VDYSG------CGSNEEAMNREGNK--SLGPP--------P 
Methanocaldococcus jannaschii   VGKALMNTKEILNADKGVAVDVERVYMDRGTYPRMWKRKK-------------------------------------------------------------------------------- 

                                        490       500       510       520       530       540       550       560       570       580       590       600           
                                ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
                                ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~|NL|~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
Homo sapiens                    --------------------------------KRKRESESESDETPPAAPQLI-------KKEKKKSKKDKK------AKAGLESGAEPGDGDSD--TTKKKKKKKKAKEVELVSE---- 
Rattus norvegicus               --------------------------------KRKRDSDSDADEATPTTTPRV-------KKEKKK-KKEK----------ADGGEEAAEDGDGD--ATRKKKKKK-ARAAEELSG---- 
Mus musculus                    --------------------------------KRKRDSESES-DETPTVPQLK-------EKKKKKDKKPK---------TVLESGGETGDGDND--TTKKKKKKK-VKVVEEMSE---- 
Bos taurus                      --------------------------------KRKRESESE--DTSPAAPQVV-------KKEKKKKKKEK-------AKAAAEK---PGAGDSD--STKKKKKKK--IKAEMVSE---- 
Gallus gallus                   --------------------------------KRKRESESENEAVSPPPSPATPPPEELSKKEKKKKKKEKK------AKEAAESGEEQ-VEVISESSAKKKKKKKKQKEVEESSE---- 
Danio rerio                     --------------------------------KRKRD-ESGSEGEAAAAAQDTSKTEEESKKEKKKKKKEKK------QKLAEEAAAEAPAEEETEVTESAKKKKKKKK----------- 
Drosophila melanogaster         --------------------------------KRKLST-SSVEETAAAAVSEET-PSKDKKKKKKKHKGDEE----------APEAAEEEA-EPVEKEKKKKKKKDKDRDRDEAQE---- 
Anopheles gambiae               --------------------------------KRKLSIGENVES-----AATIG-DGEEKKKKKKKQKKDAEDGDGEAVGAEGQPMDQAEGDEEMKKEKKKKKKKDKNVSVDEVAE---- 
Aedes aegypti                   --------------------------------KRKLSVGSAADQSMETSAMEVD-AGEKKKKKKKKHKKDDE--APEAP--ETPEAVEVEATEEVSETK--KKKKKKDKKQEEEAE---- 
Culex pipiens quinquefasciatus  --------------------------------KRKLSIGSAADNSMDTSAIDAG-EGKEKKKKKKKQKQDEE--APEEAAAEATEPAEADATEETSESKKEKKKKKKDKKQQEEAE---- 
Caenorhabditis elegans          --------------------------------KKEVKKEETPDEE---------EEEAPKKKSKKSKKQESSDSDSD------------------------------------------- 
Schizosaccharomyces pombe       --------------------------------KKRKSVESSEKDED----EAAKKEEKRRKKEAKKEKKEKKEKK--------------EKKE-------KKKKSE-------------- 
Saccharomyces cerevisiae        -------LIKEVETEKEEVKED----------------DSKKEKKEKKDKKEKKEKKEKKDKKEKKEKKEKKRKS--------------EDGD--SEE-KKSKKSKK------------- 
Kluyveromyces lactis            ----KKEVEQKEESKEESKTPE-----------------------EKKDKKEKKEKKDKKEKKEKKEKKEKKRKA--------------DDDE--SSE-KKKKKSKK------------- 
Ashbya gossypii                 ----KKDAKTEVEVPAEKKQDD-------------EEKKEKKEKKEKSEKKEKKEKKEKSEKSEKKEKKEKKRKA--------------DDEN--ASEEKKKKKSKK------------- 
Lodderomyces elongisporus       ----KKTLIEEVEVST------------------------VEVDGDKKEKKEKKDKKDKKDKKDKKDKKEKKRKA--------------EDDEGESSKSEKKKKSKKD------------ 
Pichia stipitis                 ----KKTLIEEVASEEASEA--------------------EEKKEDKKEKKEKKEKKEKKDKKEKKDKKDKKRKA--------------EDGE---EKAEKKKKAKK------------- 
Pichia guilliermondii           ----KKLIEEVETKSSLDDDM------------------EEESKKEKKEKKEKKEKKEKKEKKEKKEKKEKKRKS--------------EDGE---TESGKKKKSKKE------------ 
Zygosaccharomyces rouxii        ----KKDEEEKKEEKKEEKKEEKEEKKEEAEESDDEEKSDKKSKKEKKDKKEKKDKKEKKEKKEKKEKKEKKRKA--------------DDDE--DGE-SKKKKSKK------------- 
Aspergillus fumigatus           EAPSSPQSKMDVDETKEE-------------KKRKRHEG----------ETAEERAERKRKKKEKKEKKERRKSKQEKE---------DSDDSD-------------------------- 
Aspergillus clavatus            EAPSSPQSKMDVDEDKDE-------------KKRKRHEG----------ETPEERAERKRKKKEKKEKKERRKSKQEKD---------DSDDSD-------------------------- 
Aspergillus nidulans            PSLEANESKMDIDDAQDDE----------DKKKRKRHEG----------ETPEERAERKRKKKEKKEKKERRKSKQEKD---------DSDDSD-------------------------- 
Chaetomium globosum             SPQKQIEAAPATEEKADE-----------ESKKRKKHEG----------ETAEEKAERKRLKKEKKEKKEKKKGKEAA----------DESD---------------------------- 
Magnaporthe grisea              KALPAPEAEPEAEADDGK-------------KRKSKHEG----------ETAEEKAERKRRKKEKKEKRASKAAAE------------EDSD---------------------------- 
Neurospora crassa               ERPKPEEKAEKSEEAEEAG----------DSKKRKKHDG----------ETAEEKAERKKQKKEKKEKKEKKEKKSKKGG--------DESD---------------------------- 
Botryotinia fuckeliana          LAPVDGNAAEDDEEKSD--------------KKRKRHDG----------ETAEEKAERKRKKKEKKAKRESKKS----AG--------GSSDSE-------------------------- 
Pyrenophora tritici-repentis    GLTSTEEAEAEAEAGAADA--------DSKKSKKRKSRG------DGEEEADEDKAERKKKKKEEKAAKKAAKKDKRKSKG------GDDSDSD-------------------------- 
Neosartorya fischeri            EAPSSPQSKMDVDETKEE-------------KKRKRHEG----------ETAEERAERKRKKKEKKEKKERRKS-KQEKE--------DSGDSD-------------------------- 
Coccidioides immitis            ASSPAP------EADKED------------AKKRKRHDG----------ETPEEREERKRRKKEKKEEKEKRKQEKKEKKERRKSKQADSSDSE-------------------------- 
Dictyostelium discoideum        KAEVESSEDEKPVPKKEKKD-----------KKEKKKDSS--------DDESEEEKSSKKDKKEKKEKKEKKEKKSSKDDSDDESSKKEKKDKKRKKSSDKDSDSEKESSDKKDKKDKKE 
Arabidopsis thaliana            DSPAPVTTKKSKTKEVEGEEAEEK---VKSSKKKKKKDK-----------EEEKEEEAGSEKKEKKKKKDKKEEVIEEVASPKSEKKKKKKSKDTEAAVDAEDESAAEKSEKKKKKKDKK 
Chlamydomonas reinhardtii       -------------------------------PVEIKEEG----------------------KKEKKVRRWGKS----------------------------------------------- 
Cryptosporidium parvum          NDEESSSSFSSKN----------KKEKNKRKSTEPLSENGSSSSSSDSSSSNSSSDDEKSKSKGKKSSKDKSKKKKKHSR--------ISED---------------------------- 
Euglena gracilis                KVRIEELAYAEAAKKRER------------------------------EAAGEDEKDAKKAKKEKKEKKEKKEKK-------------EKAEKTA------------------------- 
Methanocaldococcus jannaschii   ------------------------------------------------------------------------------------------------------------------------ 

                                        610 
                                ....|....|.

Homo sapiens                    ----------- 
Rattus norvegicus               ----------- 
Mus musculus                    ----------- 
Bos taurus                      ----------- 
Gallus gallus                   ----------- 
Danio rerio                     ----------- 
Drosophila melanogaster         ----------- 
Anopheles gambiae               ----------- 
Aedes aegypti                   ----------- 
Culex pipiens quinquefasciatus  ----------- 
Caenorhabditis elegans          ----------- 
Schizosaccharomyces pombe       ----------- 
Saccharomyces cerevisiae        ----------- 
Kluyveromyces lactis            ----------- 
Ashbya gossypii                 ----------- 
Lodderomyces elongisporus       ----------- 
Pichia stipitis                 ----------- 
Pichia guilliermondii           ----------- 
Zygosaccharomyces rouxii        ----------- 
Aspergillus fumigatus           ----------- 
Aspergillus clavatus            ----------- 
Aspergillus nidulans            ----------- 
Chaetomium globosum             ----------- 
Magnaporthe grisea              ----------- 
Neurospora crassa               ----------- 
Botryotinia fuckeliana          ----------- 
Pyrenophora tritici-repentis    ----------- 
Neosartorya fischeri            ----------- 
Coccidioides immitis            ----------- 
Dictyostelium discoideum        KKKSKN----- 
Arabidopsis thaliana            KKNKDSEDDEE 
Chlamydomonas reinhardtii       ----------- 
Cryptosporidium parvum          ----------- 
Euglena gracilis                ----------- 
Methanocaldococcus jannaschii   -----------