10        20        30        40        50        60        70        80        90       100       110       120                    
                      ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
motif                                                                                              |------------------------------------------ 
Homo sapiens          -----------------MPRAPRCRAVRSLLRSHYREVLPLATFVRRLGPQGWR---LVQRGDPAAFRALVAQCLVCVPWDARPPPAAPSFRQVSCLKELVARVLQRLCERGAKNVLAFG 
Mesocricetus auratus  -----------------MPRAPRCRAVRALLRSQYRQVWPLATFVRRLGPEGRQ---LVQPGDPKVFRTLVARCLVCVPWDSQPPPADLSFHQVSSLKELVARVVQRLCERGERNVLTFG 
Mus musculus          -----------------MTRAPRCPAVRSLLRSRYREVWPLATFVRRLGPEGRR---LVQPGDPKIYRTLVAQCLVCMHWGSQPPPADLSFHQVSSLKELVARVVQRLCERNERNVLAFG 
Rattus norvegicus     -----------------MPRAPRCPAVRSLLRSRYREVWPLATFVRRLGLEGSR---LVQPGDPKVFRTLVAQCLVCVPWGSQPPPADLSFHQVSSLKELVSRVVQKLCERGERNVLAFG 
Canis familiaris      -----------------MPRAPRCRAVRALLRGRYREVLPLATFLRRLGPPGRL---LVRRGDPAAFRALVAQCLVCVPWGARPPPAAPCFRQVSCLKELVARVVQRLCERGARNVLAFG 
Bos taurus            -----------------MPRAPRCRAVRALLRASYRQVLPLAAFVRRLRPQGHR---LVRRGDPAAFRALVAQCLVCVPWDAQPPPAAPSFRQVSCLKELVARVVQRLCERGARNVLAFG 
Coturnix japonica     MERGADPGVGVRRRLHNMARAEPFAAVLGALRGCYAEATPLEAFVRRLQDGGTGEVEVLRGDDAQCYRTFVSQCVVCVPRGARPIPRPICFQQLSSQNEVITRIIQRLCEKKKKNILAYG 
Gallus gallus         MERGAQPGVGVRR-LRNVAREEPFAAVLGALRGCYAEXTPLEAFVRRLQEGGTGEVEVLRGDDAQCYRTFVSQCVVCVPRGARAIPRPICFQQLSSQSEVITRIVQRLCEKKKKNILAYG 
Xenopus laevis        -----------------MPLRTGGATLLSILQRLYGQVLGIVEYTDTLQVPGGIKVPVLLEGDSEKFRSFVAELVVCIPRGTKPLPSPVSFLQLSTQREVVARVIQRICEKKRKNVLAFG 
Oryzias latipes       ------------------MTSGDLSSVLNILRSLYKRTRTLEEFADGVVFREGRRAALLQPSDTHSFKSFVRGVFVCSDEELQDVPSC---NQTCTFPELLAFILNSLKRKRRRNVLAHG 
Oryzias melastigma    ------------------MTSEDVSRVLELLRSLYKRTQTLQEFADGVVFRDGRRATLLQPSDSIVFQTFVRAVFVCSDEELREVRSS---KQICTFSEILAFVLNNLKRSKSNNVLAQG 
Epinephelus coioides  ------------------MSTADLSPTLDILRSVYQHVQTLEQFTDSIVFREGHRAQLTEHTDTNRFKSFVRGVFVCFDRELQQVPSC---NRICTLPELLAFVLNSLKRKRKRNILAHG 
Takifugu rubripes     ------------------MSITDLSPTLGILRSLYPHVQVLVDFADDIVFREGHKATLIEESDTSHFKSFVRGIFVCFHKELQQVPSC---NQICTLPELLAFVLNSVKRKRKRNVLAHG 
Danio rerio           -------------MSGQYSTDGGFRPVLEILRSLYPVVQTLEEFTDGLQFPDGRKPVLLEETDGARFKKLLSGLIVCAYT-PPQLRVP---AQLSTLPEVLAFTLNHIKRKKLRNVLGFG 
region                |-----------------------------------------region v-Ia----------------------------------|                                 
                                                                    |-----------------------------------------------------------------------RI 
                                                                                                               |-------------------------DAT d 

                              130       140       150       160       170       180       190       200       210       220       230       240           
                      ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
motif                 -motif GQ------------------------------------------------------------------------------------|                           
Homo sapiens          FALLDGARGGPPEAFTTSVRSYLPNTVTDALRGSGAWGLLLRRVGDDVLVHLLARCALFVLVAPSCAYQVCGPPLYQLGAATQARPPPHASGPR--------------RRLGCERAWNHS 
Mesocricetus auratus  FALLNGAQGGPPMTFTTSVRSYLPNSVTESLRVSGAWMLLLNRVGDDLLVYLLARCALYLLVPPSCAYQVCGSPLYQICATAETWPSVSRIYRPTRPVG-----RNFTHLGSTHRVRNSS 
Mus musculus          FELLNEARGGPPMAFTSSVRSYLPNTVIETLRVSGAWMLLLSRVGDDLLVYLLAHCALYLLVPPSCAYQVCGSPLYQICATTDIWPSVSASYRPTRPVG-----RNFTNLRFLQQIKSSS 
Rattus norvegicus     FALLNGARGGPPMAFTTSVHSYLPNSVTESLCVSGAWMLLLSRVGDDLLVYLLSHCALYLLVPPSCAYQVCGSPLYQICATTDTWSSVPAGYRPTRPVG-----GNFTNLGSAHQIKNSG 
Canis familiaris      FALLDGARGGPPVAFTTSVRSYLPNTVTETLRGSGAWGLLLRRVGDDVLTHLLARCALYLLVAPSCAYQVCGPPLYDLCAPASLPLPAPGLPGLPGLPG--------------LGAGAGA 
Bos taurus            FTLLAGARGGPPVAFTTSVRSYLPNTVTDTLRGSGAWGLLLHRVGDDVLTHLLSRCALYLLVPPTCAYQVCGPPLYDLRAAAAAARRPTRQVGGTRAGF----------GLPRPASSNGG 
Coturnix japonica     YSLLDENSCHFRVLPSSCIYSYLSNTVTETIRISGLWEILLSRIGDDVMMYLLEHCALFMLVPPSNCYQVCGQPVYELISRNIGPSPGFVRRRYSRFKHNSLLDYVRKRLVFHRHYLSKS 
Gallus gallus         YSLLDENSCHFRVLPSSCIYSYLSNTVTETIRISGLWEILLSRIGDDVMMYLLEHCALFMLVPPSNCYQVCGQPIYELISRNVGPSPGFVRRRYSRFKHNSLLDYVRKRLVFHRHYLSKS 
Xenopus laevis        YGLVDE-KNSLNIRLTPNICNYFPNPTTTTISTSILWETLLTRVGDDVMMYWLEQCSIFVFVPPRCCYQITGQPIYTLPSDDVFLFQSQSFTQSNVLLRYIKRNVFHLRKKYLKPKHSMT 
Oryzias latipes       YNFLGVAQEDRDADHFRFQGD-LSQSAAY-IHSSDLWKKVTARLGTDVTRYLLGSCSVFVLAPPSCIFQICGVPAYDRVSMTTASSGFLLRPPSRKHKSFQVGKKRRSANLTKRGSVGDV 
Oryzias melastigma    YNWKT-AQENKDVNLFRFQGD-LSQSANY-IHSSEQWKKVMAHLGPDFLLHLLGSFSVFVVAPPSCVFQICGAPAYDRVSVTTASSRFLLKHPSRRHTSSRLGKNRCSVKFKMRDSAEDE 
Epinephelus coioides  YSFLSLAQEERDADHFKSQGD-ITQSAAY-IHGSDLWKKVTIRLGTDITRYLLESCSVFVAVPPSCVFQVCGAPVYDRVSMTTAPAGFCLQSRARTLNGGQAGRNRGAVTVRRKHKVEND 
Takifugu rubripes     YNFQSLAQEERDADQFKLQGD-VTQSAAY-VHGSDLWRKVSMRLGTDITRYLFESCSVFVAVPPSCLFQVCGIPIYDCFSLATASLGFSLQSRG--CRERCLGVNSMKRRAFNVKRYLRK 
Danio rerio           YQCSDVTTS---SDPFRFHGD-VSQTAAS-ISTSEVWKRINQRLGTEVTRYLLQDCAVFTTVPPSCVLQVCGEPVYDLLMPRSWSGFFLSNSDNERISGAMRKFPAVQKTVAISKKRTRD 
region                                                 |-------------region v-Ib----------------|                                              
                      D1--------------------------------------------------------|                                                              
                      omain-------------------|        |--------------motif T2------------------|                                              

                              250       260       270       280       290       300       310       320       330       340       350       360           
                      ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
motif                                                                                                                                          
Homo sapiens          VREAGVPLGLPAPGARRRGGSASRSLPLPKRPR--------------------------------------------------------------------------------------- 
Mesocricetus auratus  HQEAWKPPPLPSREAKRSLSITNRSVPPSKKAR--------------------------------------------------------------------------------------- 
Mus musculus          RQEAPKPLALPSRGTKRHLSLTSTSVPSAKKAR--------------------------------------------------------------------------------------- 
Rattus norvegicus     HQEAPKPQALPSRGTKRLLSLTSTNVPSAKKAR--------------------------------------------------------------------------------------- 
Canis familiaris      SADLRPTRQAQNSGARRRRGSPGSGVPLAKRPR--------------------------------------------------------------------------------------- 
Bos taurus            HGEAEGLLEARAQGARRRRSSARGRLPPAKRPR--------------------------------------------------------------------------------------- 
Coturnix japonica     QWWKCKPRHQGHVSSRRKRSQ-RIQSLRPGYQSSEKVDFQAGRHISIVNAHMEKQSCSSLCLPNRAPSLKRKRDGEQVEIAAKRVKVMEKEIEKQACSIIPDVNQSSSQRH-RTWHVAPR 
Gallus gallus         QWWKCRPRRRGRVSSRRKRRSHRIQSLRSGYQPSAKVNFQAGRQISTVTARLEKQSCSSLCLPARAPSLKRKRDGEQVEITAKRVKIMEKEIEEQACSIVPDVNQSSSQRHGTSWHVAPR 
Xenopus laevis        SRMLTWRRNKSPSGLLIRSKTSMAVTTEIHSKRKLCSKDICVIPDKKRRDNLDKDDTVDHFDLPMCRSVSYL------------------------------------------------ 
Oryzias latipes       EESRKRRRVESGVSARKRKREPEEEESRERRRG--------------------------------------------------------------------------------------- 
Oryzias melastigma    EKRRKKRRVESTNSSRKRKREPEEEESSKRRCD--------------------------------------------------------------------------------------- 
Epinephelus coioides  KRNRRVKKRQRQ--ADEKDEEEVMTCPGKRRRVG-------------------------------------------------------------------------------------- 
Takifugu rubripes     RKTETDQKDE------------ARVCSGKRRRV--------------------------------------------------------------------------------------- 
Danio rerio           NEKYISVKRRRVKETVNNNNGNYRSLCFAISKKRAIDNEENISLKRRR------------------------------------------------------------------------ 
region                                                                                                                                         

                              370       380       390       400       410       420       430       440       450       460       470       480           
                      ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
motif                                                                                                                                          
Homo sapiens          ----------------------------RGAAPEPERTPVGQGSWAHPGRTRGPSDRGFCVVSPARPAEEATSLEGALSGTRHSHPSVGRQHHAGPPSTSRPPRPWDTPCPPVYAETKHF 
Mesocricetus auratus  ------------------------------CDLAPRLEKGPYRQAVPTPSDKTWVPNPAKSHAVPISRTTKEDLSSGVKAPGLSRSGSVCYKHKPSSTSLQSPLCQNAFQLRPYTETKRF 
Mus musculus          ---------------------------------CYPVPRVEEGPHRQVLPTPSGKSWVPSPARSPEVPTAEKDLSSKGKVSDLSLSGSVCCKHKPSSTSLLSPPRQNAFQLRPFIETRHF 
Rattus norvegicus     ---------------------------------FEPALRVDKGPHRQVVPTPSGKTWAPSPAASPKVPPAAKNLSLKGKASDPSLSGSVCCKHKPSSSSLLSSPPQDAEKLRPFTETRHF 
Canis familiaris      --------------------------------------------RSVASEPERGAHRSFPRAQQPPVSEAPAVTPAVAASPAASWEGGPPGTRPTTPAWHPYPGPQGVPHDPAHPETKRF 
Bos taurus            --------------------------------------------RGLEPGRDLEGQVARSPPRVVTPTRDAAEAKSRKGDVPGPCRLFPGGERGVGSASWRLSPSEGEPGAGACAETKRF 
Coturnix japonica     AVGLIKERYISERSNSEMSGPSVVHRSHPGKRPVADKSSFPQGVQGNKRVKTGAEKRVESNRRGTEMCINPTHKPNRRGVERRINPSHKPGLNSVQTEPMEGASSGDRKQENPPAHLAKQ 
Gallus gallus         AVGLIKEHYISERSNSEMSGPSVVHRSHPGKRPVADKSSFPQGVQGNKRIKTGAEKRAESNRRGIEMYINPIHKPNRRGIERRINPTHKPELNSVQTEPMEGASSGDRKQENPPAHLAKQ 
Xenopus laevis        ------------------------------------SNMYPKTNVQVTGLITSGYKKTKTFQCQKPVSCEQKKTTAFYSVAGDCNLSLKDNVNKLITNASVPTAQSRLSFSNIFIDFGRT 
Oryzias latipes       ---------------------------------------------------VHHEERRQHEAVLDESTLSGKSGENDAAAVKPPPETSAAPPPLEGGPSWRSGAFPPLPSSQCFIRTLGF 
Oryzias melastigma    ----------------------------------------------------THHEESSQHACSEAVLVESTVSENDKSSLKMPPETSAASLPLEGEPSWRSGTFPPLPSSQCFIRTMGL 
Epinephelus coioides  ------------------------------------------QHEHTQEVQVCSESVGEGQPTSVEPSLTLKTLENGATVSKQPAETQTTTLPLEGGPSWRSGMFPPLPPSQCFIRTLGF 
Takifugu rubripes     -----------------------------------------------------MEEDKVSCETMQDGESGKTTLVQKQPGSKKRSEMEATLLPLEGGPSWRSGTFPPLPPSQSFMRTLGF 
Danio rerio           ----------------------------------------MEETDQVAKIRNENHESQSFAISKKRARDNEENISLKRQRMEEIDQVAKIRNENHGSQSWKPADQRPPRPSQCSIRVLSM 
region                                                                                                                                         

                              490       500       510       520       530       540       550       560       570       580       590       600           
                      ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
motif                                                         |-motif VSR-|                                    |--------motif CP-----------|   
Homo sapiens          LYS--SGDKEQLRPSFLLSS---------------LRPSLTGARRLVETIFLGSRPWMPGTPRRLP-------RLPQRYWQMRPLFLELLGNHAQCPYGVLLKTHCPLRAAVTPAAGVCA 
Mesocricetus auratus  LYS-REGGRERLNPSFLLNN---------------LQPSLTGARRLVEILFLGMRPRTSGPLCGRR-------RLSKRYWQMRPLFQQLLVNHARCPYVRLLRSHCRFRTAAHQVAGA-- 
Mus musculus          LYS-RGDGQERLNPSFLLSN---------------LQPNLTGARRLVEIIFLGSRPRTSGPLCRTH-------RLSRRYWQMRPLFQQLLVNHAECQYVRLLRSHCRFRTANQQVTDA-- 
Rattus norvegicus     LYS-RGGGQEELNPSFLLNS---------------LPPSLTGARRLVEIIFLGSRPRTSGPFCRTR-------RLPRRYWQMRPLFQQLLMNHAKCQYVRFLRSHCRFRTANQRVPDA-- 
Canis familiaris      LYC--SGGRERLRPSFLLSA---------------LPPTLSGARKLVETIFLGSAPQKPGAARRMR-------RLPARYWRMRPLFQELLGNHARCPYRALLRTHCPLRAMAAKEGSGNQ 
Bos taurus            LYC--SGGGEQLRRSFLLCS---------------LPPSLAGARTLVETIFLDSKPGPPGAPRRPR-------RLPARYWQMRPLFRKLLGNHARSPYGALLRAHCPLPASAPRAGPDHQ 
Coturnix japonica     LPNRFLRSAVYFEKKFLLYSRNYQEYFPKSFILSRLQDCQAGGRRLIETIFLSQNPVKEKQNQSLPQQKWRK-KLPKRYWQMRELFQKLVKNHKTCPYLVFLRKNCPVLLSEACLEKTEL 
Gallus gallus         LPNTLSRSTVYFEKKFLLYSRSYQEYFPKSFILSRLQGCQAGGRRLIETIFLSQNPLKEQQNQSLPQQKWRKKRLPKRYWQMREIFQKLVKNHEKCPYLVFLRKNCPVLLSEACLKKTEL 
Xenopus laevis        LYL-SISYKKGFSESFILNS---------------LDSTPSGSQKLVETIFLSNFLAEQNFDQPKRDENCRY-KLPKRYWKMKPHFQELIQNHKKFPYLVYLNKHCPVRSSMACSEKR-- 
Oryzias latipes       LYGGRGMHGFCLNRKRRTAA---------------GPRRLQGQDLVRLVFFEGLPYLNGQERKPK--------KLPLRYFNMVPVFGRLLQRHRKCRYSSVLHRMCPVVELSRAAQG--- 
Oryzias melastigma    LYGGQGMQGFCLNRKKQTAA---------------GLRRLQGQDLVRLVFFQGLPYLDKQTRDPK--------KLRLRFFRMVPVFGELLQRHRKCPYTRVLQRMCPLVEESRAAPG--- 
Epinephelus coioides  LYGGRGMRGFLLNRKKKTPD---------------GCRRLQGTDLVRIVFFEGLAYLNGLERKPK--------KLPRRFFTMVPVFSRLLRQHRRCPYSRILQRMCPVVEDRNTQQE--- 
Takifugu rubripes     LYGGRGMRSFLLNRKKKTAE---------------GFRKIQGRDLIRIVFFEGVLYLNGLERKPK--------KLPRRFFNMVPLFSQLLRQHRRCPYSRLLQKTCPLVGIKDAGQA--- 
Danio rerio           LYNGRGMKNFLLNRKLKGVG---------------GARRMQGEDLVRMIFLQ----SESNDSKPK--------KLPKRFFAMVPLFSRLLRQHRKCPYRLFLQRKC----AGNPDVK--- 
region                                                                           |--------------------region v-II------------------|           
                                                         |------------------------------------------------------------------------------------ 

                              610       620       630       640       650       660       670       680       690       700       710       720           
                      ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
motif                                                                        |--------------------------------motif QFP----------------------- 
Homo sapiens          REK-------------------------------------PQGSVAAPEEEDTDPRRLVQLLRQHSSPWQVYGFVRACLRRLVPPGLWGSRHNERRFLRNTKKFISLG-KHAKLSLQELT 
Mesocricetus auratus  -------------------------------------------------LNTTSPQRLMNLLRLHSSPWQVYGFLQACVGKLVPPGLWGSRHNQRRFFKNVKRFISLG-KYDKLSLQELT 
Mus musculus          --------------------------------------------------LNTSPPHLMDLLRLHSSPWQVYGFLRACLCKVVSASLWGTRHNERRFFKNLKKFISLG-KYGKLSLQELM 
Rattus norvegicus     --------------------------------------------------MDTSPSHLTSLLRLHSSPWQVYGFLRACLRELVPAGLWGTRHNERRFLKNVKKFISLG-KYAKLSLQELM 
Canis familiaris      AHR--------------------------------GVGICPLERPVAAPQEQTDSTRLVQLLRQHSSPWQVYAFLRACLCWLVPTGLWGSRHNQRRFLRNVKKFISLG-KHAKLSLQELT 
Bos taurus            KCP--------------------------------GVGGCPSERPAAAPEGEANSGRLVQLLRQHSSPWQVYGLLRACLRRLVPAGLWGSRHNERRFLRNVKKLLSLG-KHGRLSQQELT 
Coturnix japonica     TLQVALPGEAKVPKHTEHGKESTEGAALNSFHAPPSMPVCGQSERGEQHPAEGSDPLLGELLRQHSSHWQVYGFVRECLERVIPAELWGSSHNKCRFLKNVKAFISMG-KYDKLSLQQLM 
Gallus gallus         TLQAALPGEAKVHKHTEHGKESTEGTAPNSFLAPPSVLACGQPERGEQHPAEGSDPLLRELLRQHSSHWQVYGFVRECLERVIPAELWGSSHNKCRFFKNVKAFISMG-KYAKLSLQQLM 
Xenopus laevis        -----------------------------------SLQKNRIENDGKQLKHFTTKANLLSLLKQHSSIWQVYMFVRECLNNVVPDIMWGSSHNKCRFFRNVKSFLFFSGKFGKISLSELM 
Oryzias latipes       --------------------------------------------------------ELSSLIPQHCAPHRVYLFVRECLTAVVPEELWGSDHNRLQFFSRVRGFLKSG-KFERISVAELM 
Oryzias melastigma    --------------------------------------------------------QPSSLIPLHCDPHRVYLFVRACLITVVPEELWGSDHNRLQFFTKVRCFLKNG-KFERVSVAELM 
Epinephelus coioides  --------------------------------------------------------DLSSLLPRHCAPHRVYLFVRECLTAVIPPELWGSDHNRLHFFSRVRGFLRSG-KFERLSLAELM 
Takifugu rubripes     --------------------------------------------------------ELSSFLPQHCGSHRVYLFVRECLLAVIPQELWGSEHNRLLYFARVRFFLRSG-KFERLSVAELM 
Danio rerio           --------------------------------------------------------DMESLLKSHSSPYRVYLFVRECLRHIIPHELWGCQENQLHFLSNVKNFLLLG-KFERLTLVQLM 
region                                                                                         |---------------------------------------region  
                      ---------------RID1----------------------------------------------------------------------------------------------------- 

                              730       740       750       760       770       780       790       800       810       820       830       840           
                      ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
motif                 ----------|                      |--------------------motif T------------------------|                         |-motif 1 
Homo sapiens          WKMSVRDCAWLRRSPGVGCVPAAEHRLREEILAKFLHWLMS-VYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRELSEAEVRQHREARPALLTSRLRFIPKPD 
Mesocricetus auratus  WKMKVQDCRWLRSSPGNNCVPAAEHRTRERILAVFLFWLMD-AYVVELLRSFFYVTETTFQKNRLFFYRKSMWRRLQSIGVRHHLERVRLQELSQEEVRQRQEAWPAMPICRLRFIPKPS 
Mus musculus          WKMKVEDCHWLRSSPGKDRVPAAEHRLRERILATFLFWLMD-TYVVQLLRSFFYITESTFQKNRLFFYRKSVWSKLQSIGVRQHLERVRLRELSQEEVRHHQDTWLAMPICRLRFIPKPN 
Rattus norvegicus     WRVKVEDCHWLRSSPEKDTVPAAEHRLRERILAMFLFWLMD-TYVVQLLRSFFYITETTFQKNRLFFYRKSVWSKLQSIGIRQQLERVQLRELSQEEVKHHQDTWLAMPICRLRFIPKLN 
Canis familiaris      WKMKVRDCTWLHGNPGACCVPAAEHRRREEILARFLVLVDGHIYVVKLLRSFFYVTETTFQKNRLFFYRKSVWSQLQSIGIRQLFNSVHLRELSEAEVRRHREARPALLTSRLRFLPKPS 
Bos taurus            WKMKVQDCAWLRASPGARCVPAAEHRQREAVLGRFLHWLMG-AYVVELLRSFFYVTETTFQKNRLFFFRKRIWSQLQRLGVRQHLDRVRLRELSEAEVRQHQEARPALLTSRLRFVPKPG 
Coturnix japonica     WKMRVNDCVWLRLAKGNHSVPAYEHCYREEILAKFLYWLMD-SYVIELLKSFFYITETMFQKNTLFYYRKFIWGKLQNIGIRNHFAKVHLRALSSEEMDVIRQKKYFPIASRLRFIPKIN 
Gallus gallus         WKMRVNDCVWLRLAKGNHSVPAYEHCYREEILAKFLYWLMD-SYVIELLKSFFYITETMFQKNMLFYYRKFIWGKLQNIGIRDHFAKVHLRALSSEEMEVIRQKKYFPIASRLRFIPKMN 
Xenopus laevis        WSMRVEDCSWIRLQKSDHFVPASEHLLREKILAKFVFWLMD-TYVIQLLKSFFYVTETMFQKHRLLFYRKSVWKKLQNIGLRKHLEKVKLRSLSSDELENMQQWKNVPLVSRLRFIPKTN 
Oryzias latipes       WKIKVMDCDWLKLRRTAGRFPPSELAYRTRILSQFLTWLLD-GFVVGLVRACFYATESVGQKNAIRFYRQEVWSKLQDLAFRRHIAKGEMEELSPAQVASLP---KGTVISQLRFIPKTD 
Oryzias melastigma    WKMKVMDCDWLKLRRTG-RFPPSELTYRTQILSLFLTWLLD-GFVVGLVQACFYATDSVGQKSTIRFYRPEVWNKLRDLAFRNHVAKGQMEELTPDQVASLP---KDAIISQLRFIPKAD 
Epinephelus coioides  WKMKVNDCDWLKISKTG-RFPPSELSYRTQILGQFLAWLLD-GYVVSLVRACFYVTESVGQKNAVRFYRQEVWAKLQDLAFRGHLSKGQMEELTPAQVASLP---KTTVISRLRFIPKTD 
Takifugu rubripes     WKIKVNNCDWLKISKTG-RVPPSELSYRTQILGQFLAWLLD-GFVVGLVRACFYATESMGQKNAIRFYRQEVWAKLQDLAFRSHISKGQMVELTPDQVAALP---KSTIISRLRFIPKTD 
Danio rerio           WRMKVQACHWLGPKKRQ---CASEHRYREWMLGQCMGWMLS-GFVVGLVRAQFYITESMGHKHTLRFYRGDVWSRLQDQAFRAHLCKGQWRPLSPSQALKVP---NSAVTSRIRFIPKTS 
region                v-III-----------------------------------------|   |---------------------region v-IV----------------|                     
                      -------------------------------------|                                                                                   

                              850       860       870       880       890       900       910       920       930       940       950       960           
                      ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
motif                 ||-2-|                                                                         |---------motif A------------|            
Homo sapiens          GLRPIVNMDYVV---GARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVR-AQDPPPELYFVKVDVTGAYDTIPQDRLTEVIASIIKPQ--NTYCVR 
Mesocricetus auratus  GLRPIVNMSYM----GTRAFDKGKQAQHFTQCLKTLFSVLNYELTKHTNLLGASVLGLNDIYRTWRTFVLRVR-TLDPAPRMYFVKADVTGAYDAIPQDKLVEVIANMIRHPD-NSYCIH 
Mus musculus          GLRPIVNMSYSM---GTRALGRRKQAQHFTQRLKTLFSMLNYERTKHPHLMGSSVLGMNDIYRTWRAFVLRVR-ALDQTPRMYFVKADVTGAYDAIPQGKLVEVVANMIRHSE-STYCIR 
Rattus norvegicus     GLRPIVNMSYGM---DTRAFGKKKQTQCFTQSLKTLFSVLNYERTKHPNLMGASVLGTSDSYRIWRTFVLRVR-ALDQTPRMYFVKADVTGAYDAIPQDKLVEIVANIIRRSE-SMYCIR 
Canis familiaris      GLRPIVNMDYIM---GARTFHRDKKVQHLTSQLKTLFSVLNYERARRPSLLGASMLGMDDIHRAWRTFVLRIR-AQNPAPQLYFVKVDVTGAYDALPQDRLVEVIANVIRPQE-STYCVR 
Bos taurus            GLRPIVNVGCVE---GAPAPPRDKKVQHLSSRVKTLFAVLNYERARRPGLLGASVLGMDDIHRAWRAFVLPLR-ARGPAPPLYFVKVDVVGAYDALPQDKLAEVIANVLQPQE-NTYCVR 
Coturnix japonica     GLRPIVRLSRVVEGQKLSKESREKKIQRYNTQLKNLFSVLNYERTVNTSIIGSSVFGRDDIYRKWKEFVTKVFESGGEMPHYYFVKGDVSRAFDTIPHKKLVEVISQVLKPESQTVYGIR 
Gallus gallus         GLRPVVRLSRVVEGQKLSKESREKKIQRYNTQLKNLFSVLNYERTVNTSIIGSSVFGRDDIYRKWKEFVTKVFESGGEMPHFYFVKGDVSRAFDTIPHKKLVEVISQVLKPESQTVYGIR 
Xenopus laevis        GLRPISKISSTL-SSQQSKENQEKKIHHFSSQIRNLFSVLNYEWNRNCSLIGSSVFGMDDIYKKWKKFVLDFEKPQVEKLQFYFVKTDVKGAYDTIPHSKLDEVISKVINPNANEVYCIR 
Oryzias latipes       GMRPITRVIG-----------ADSNTRLHHKRIRDLMSMLQARVRSAPALLGSTVWGMTDIHKVLRSLAPAQK---DKPQPLYFVKVDVSGAYDSLPHDKLKEVITEALSPVQEEVFTVR 
Oryzias melastigma    GMRPITRVIR-----------ADLHTRLHHWCIRDLMDLLQARVRSMPSLLGSTVWGLTDIHKVLSSLAPAQK---AKPQQLYFVKVDVSGAYESLPHDKLKQVVSEALSPIQEQVFAIR 
Epinephelus coioides  GMRPITRVVG-----------ADAKTRVYRGRVRDLLDMLRACVRSTPSLLGSTVWGMTDIHRVLRSQAPAQK---DKPQPLYFVKVDVSGAYESLPHDKLIEVIGQALSPVQDELFTIR 
Takifugu rubripes     GMRPITRVIG-----------ADAKTRLYQSHVRDLLDMLRACVCSTPSLLGSTVWGMTDIHKVLSSIAPAQK---EKPQPLYFVKMDVSGAYESLPHNKLIEVINQVLTPVLNEVFTIR 
Danio rerio           SMRPITRLSG-----------SRDTLQYFQSCVRVLQNVLSVCVREAPGPMGSTVWGWQDIHRRLQDFSPQQK---SSPRPLYFVKVDVSGAYDSLPHLKLVEVLKEVLGPFAEQSFFLR 
region                                                                                                                                         

                              970       980       990       1000      1010      1020      1030      1040      1050      1060      1070      1080          
                      ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
motif                                                                                                    |-----------motif B--------------|    
Homo sapiens          RYAVVQKAAHGHVRKAFKSHVSTLTDLQPYMRQFVAHLQET--SPLRDAVVIEQSSSLNEASSGLFDVFLRFMCHHAVRIRGKSYVQCQGIPQGSILSTLLCSLCYGDMENKLFAGIR-R 
Mesocricetus auratus  QYAVVQRDRQGQIHKSFRRQVSTLSDLQPHMGQFLKHLQDSDTSALRNSVVIEQSLSLNEASSSLFDFFLRFVRNSVVKIGGRCYVQCQGIPQGSSLSTLLCSLCFGDMENKLFAEVQ-Q 
Mus musculus          QYAVVRRDSQGQVHKSFRRQVTTLSDLQPYMGQFLKHLQDSDASALRNSVVIEQSISMNESSSSLFDFFLHFLRHSVVKIGDRCYTQCQGIPQGSSLSTLLCSLCFGDMENKLFAEVQ-R 
Rattus norvegicus     QYAVVQKDSQGQVHKSFRRQVSTLSDLQPYMGQFTKHLQDSDASALRNSVVIEQSISMNETGSSLLHFFLRFVRHSVVKIDGRFYVQCQGIPQGSSLSTLLCSLCFGDMENKLFAEVQ-Q 
Canis familiaris      HYAVVQRTARGHVRKAFKRHVSTFADLQPYMRQFVERLQET--SLLRDAVVIEQSSSLNEAGSSLFHLFLRLVHNHVVRIGGKSYIQCQGVPQGSILSTLLCSLCYGDMERRLFPGIE-Q 
Bos taurus            HCAMVR-TARGRMRKSFKRHVSTFSDFQPYLRQLVEHLQAM--GSLRDAVVIEQSCSLNEPGSSLFNLFLHLVRSHVIRIGGRSYIQCQGIPQGSILSTLLCSFCYGDMENKLFPGVQ-Q 
Coturnix japonica     WYAVIMITPTGKARKLYKRHVSTFEDFIPDMKQFVSKLQER--TSLRNAIVVEQCLTFNENSSTLFSFFLQMLHNNILEIGHRYYMQCSGIPQGSILSTLLCSLCYGDMENKLLPGIQ-K 
Gallus gallus         WYAVIMITPTGKARKLYKRHVSTFEDFIPDMKQFVSKLQER--TSLRNAIVVEQCLTFNENSSTLFTFFLQMLHNNILEIGHRYYIQCSGIPQGSILSTLLCSLCYGDMENKLLCGIQ-K 
Xenopus laevis        RYATVSVDPTGRIIKSFKRHVSELADVLPNMKQFVSNQQEK--NLLRNTILVEQNLLLNESSVKLLAVFQQIIRSHILRIKDRYYMQCCGIPQGSMLSTILCSLCYGDMENAMLGGIQ-K 
Oryzias latipes       HYAKIWADSHEGLKKAFARQVDFSDGSMGSTSMKGFVMSLQKSSKVHHAVLVEQAFGSNLRGKDALQFFTQMLTGSVVQHGKKTYRQCRGIPQGSVVSSLLCCLCYGHMENVLFRDIK-N 
Oryzias melastigma    RYAKIWRDSHEGVKKTFTKQVDFSDGDLGSSTMKNFTMALQQISNAHHSVLVEQAFTSNIQGKDAVQVFMQMLTGSIVQYENKTYRQCRGIPQGSVVSSLLCCLCYGHMERVLFRDLSKN 
Epinephelus coioides  HYAKIWADSHEGLKKSFVRQADFLEDNMGSTNMKGFVTSLQKRGKVHHAILVEQHFSSDLHGREALQFFTQMLTGSVVQFGKKTYRQCRGIPQGSVVSSLLCCLCYGHMENVLFKDITEK 
Takifugu rubripes     RFAKIWADSHEGLKKAFIRQADFLEANMGSINMKQFLTSLQKKGKLHHSVLVEQIFSSDLEGKDALQFFTQILKGSVIQFGKKTYRQCQGVPQGSAVSSVLCCLCYGHMENVLFKDIINK 
Danio rerio           QYSSVWSDPTRGLRKRFCTKAEMSEP----LNMKGFVVDEQVSGRLHDAILVER-HSSEVRGGDVFQFFQKMLCSYVIHYDQQMFRQVCGIPQGSSVSSLLCNLCYGHMEKALLKDIA-K 
region                                                                                                                                         

                              1090      1100      1110      1120      1130      1140      1150      1160      1170      1180      1190      1200          
                      ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
motif                    |----motif C----||---------motif D----------|                 |---motif E---||----------------------------motif E-I-- 
Homo sapiens          DGLLLRLVDDFLLVTPHLTHAKTFLRTLVRGVPEYGCVVNLRKTVVNFPVEDEALGGTAFVQMPAHGLFPWCGLLLDTRTLEVQSDYSSYARTSIRASLTFNRGFKAGRNMRRKLFGVLR 
Mesocricetus auratus  DGLLLRFVDDFLLVTPHLVQAEAFLRALVRGIPEYGCMINLQKTVVNFPVDAGTLDGTAPHQLPAHCLFPWCGLLLDTQTLEVLCDYTGYARTSIKASLTFQRTFKAGRNMRQKLLAVLR 
Mus musculus          DGLLLRFVDDFLLVTPHLDQAKTFLSTLVHGVPEYGCMINLQKTVVNFPVEPGTLGGAAPYQLPAHCLFPWCGLLLDTQTLEVFCDYSGYAQTSIKTSLTFQSVFKAGKTMRNKLLSVLR 
Rattus norvegicus     DGLLLRFVDDFLLVTPHLAHAKAFLSTLVHGVPEYGCMINLQKTVVNFPVETGALGGAAPHQLPAHCLFPWCGLLLDTRTLEVFCDYSGYGRTSIKMSLTFQGVSRAGKTMRYKLLSVLR 
Canis familiaris      DGVLLRLVDDFLLVTPHLTQAQAFLRTLVKGVPEYGCRANLQKTAVNFPVEDGALGSAAPLQLPAHCLFPWCGLLLDTRTLEVSCDYSSYAHTSIRASLTFSQGAKPGRNMRRKLLAVLR 
Bos taurus            DGVLLRLVDDFLLVTPHLTRARDFLRTLVRGVPEYGCQVNLRKTVVNFPVEPGALGGAAPLQLPAHCLFPWCGLLLDTRTLEVHGDHSSYARTSIRASLTFTQGFKPGRNMRRKLLAVLQ 
Coturnix japonica     DGVLIRLIDDFLLVTPHLMQARTFLRTIAAGIPEYGFVINAKKTVVNFPVDD-IPGCSKFKQLPDCRLISWCGLLLDVQTLEVYCDYSSYAFTSIRSSLSFNSSRIAGKNMKCKLTAVLK 
Gallus gallus         DGVLIRLIDDFLLVTPHLMQARTFLRTIAAGIPEYGFLINAKKTVVNFPVDD-IPGCSKFKHLPDCRLISWCGLLLDVQTLEVYCDYSSYAFTSIRSSLSFNSSRIAGKNMKCKLTAVLK 
Xenopus laevis        NGVLMRLIDDFLLVTPHLDQAKTFLRTLAEGIPQYGCSISPQKTVVNFPVDD-IPECSEVEQLPSHCLFRWCGLLLDTQTLDVYYDYSSYACTSIRSSMTFCHSSAAGKYMKQKLIRVLR 
Oryzias latipes       KGCLMRLVDDFLLITPDRNQAQSFLSILLAGVPQYGVVANPQKVVVNFQGSEGGGAFPDIRVLPPHCLFPWCGLLLDTRSLDVCKDYSSYAGLSLRYSLTLGSAHSAGQQMRRKLMSILR 
Oryzias melastigma    SGCLMRLVDDFLLITPDLNQAHTFLRIFLAGVPQYGVVANPQKVVVNFQPSEFGDAFTDVRVLPSHCLFPWCGLLLDTQSLDVYKDYSSYAGLSLRYSLTLGSTHLPGQQMRRKLMSILR 
Epinephelus coioides  KRCLMRLVDDFLLITPDLQEAQSFLRILLAGVPQYGLVVNPQKVAVNFQMLGSVGSCPGIRVLPPHCLFPWCGLLLDTHSLDVYKDYSSYAGLSLRYSLTLGSFHSAGQQMRRKLMAILR 
Takifugu rubripes     KSCLMRLVDDFLLITPNLHDAQTFLKILLAGVPQYGLVVNPQKVVVNFEDYGSTDSCPGLRVLPLRCLFPWCGLLLDTHTLDIYKDYSSYADLSLRYSLTLGSCHSAGHQMKRKLMGILR 
Danio rerio           GGCLMRLIDDFLLITPHLSKATEFLTTLLSGVPDYGCQINPQKVAVNFPVCVS-WVNSGVSVLPSSCLFPWCGLMIHTHTLDVYKDYSRYDGLSLRYSLTLGSAHSPSTVMK-KLLSVLS 
region                                                                                                |----region v-V-----|     |------------- 

                              1210      1220      1230      1240      1250      1260      1270      1280      1290      1300      1310      1320          
                      ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
motif                 -----------------------------------------|      |-------motif E-II-----|            |------------motif E-III-----------| 
Homo sapiens          LKCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFHACVLQLPFHQQVWKNPTFFLRVISDTASLCYSILKAKNAGMSLGAKGAAGPLPSEAVQWLCHQAFLLKLTRHRVTYVPLLGSLRTA 
Mesocricetus auratus  LKCHSLFLDLQMNSLQTVCINVYKIFLLQAYRFHACALQLPFDQHVRKNPAFFLSIISNIASCCYSILKVKNAGMTLKAKGASGSFPPEAARWLCYQAFLLKLAGHSVTYKCLLGPLRTA 
Mus musculus          LKCHGLFLDLQVNSLQTVCINIYKIFLLQAYRFHACVIQLPFDQRVRKNLTFFLGIISSQASCCYAILKVKNPGMTLKAS---GSFPPEAAHWLCYQAFLLKLAAHSVIYKCLLGPLRTA 
Rattus norvegicus     LKCHGLFLDLQVNSLQTVCINIYKIFLLQAYRFHACVIRLPFGQHVRKNHAFFLGIISNLASCCYAILKVKNPGVSLRAKGAPGSFPPEATRWLCYQAFLLKLAAHSVTYKCLLGPLRTA 
Canis familiaris      LKCCALFLDLQVNGIHTVYMNVYKIFLLQAYRFHACVLQLPFNQPVRKNPSFFLRVIADTASCCYSLLKARNAGLSLGAKGASGLFPSEAARWLCLHAFLLKLAHHSGTYRCLLGALQAA 
Bos taurus            LKCHGLFLDLQVNSLQTVFTNVYKIFLLQAYRFHACVLQLPFSQPVRSSPAFFLQVIADTASRGYALLKARNAGASLGARGAAGLFPSEAAQWLCLHAFLLKLARHRVTYSRLLGALRTA 
Coturnix japonica     LKCHPLLLDLKINSLKTVLINIYKIFLLQAYRFHACVLQLPFNQKVRNNPYFFLRIISDTASCCYYILKAKNPGVSLGSKDASGMFPSEAAEWLCYHAFIVKLSNHKVIYKCLLKPLKFY 
Gallus gallus         LKCHPLLLDLKINSLQTVLINIYKIFLLQAYRFHACVLQLPFNQKVRNNPDFFLRIISDTASCCYFILKAKNPGVSLGSKDASGMFPFEAAEWLCYHAFIVKLSNHKVIYKCLLKPLKVY 
Xenopus laevis        LKCHSLFLDLKVNSLRTVCINTYKIFLLQAYRFHACVVQLPFGQRVMNNPPFFLTVISDMAPCFYTTFKAKNKDLTRGYKDVSCQFNFEAVQWLSYQAFLTKLHNHKVLYKCLIGPLQNC 
Oryzias latipes       IKCHPLFLDLKTNSLESAYKNIHKLVLLQACRFHVCVQSLPFAQTVAKNPTYFQQMIWDMAHYANALIRRSNTGLVLGDGAQKGSVQYEAVELLFCLAFLRVLSKHRPVYKDLLPRLHKW 
Oryzias melastigma    LKCHPLFLDLKMNSHESVYKNIYKLVLLHACRFHVCAQSLPFSQTVAKNPSYFLQMIWDMVRYANTLIRRCNRGLVLGDKAQTGSVQFEAVKLLFCLCFQLVLSKHRPVYRDLLPHLDKC 
Epinephelus coioides  LKCHALFLDLKTNSLEAVYKNIYKLVLLHARRFHVCVQSLPFGQTVAKNPMFFLQMILDMAEYANQLIRLSNKGQILGSKAQSGVVQYEAVELLFCLSFLLVMSQHRPLYKDLLPHLHKR 
Takifugu rubripes     LKCHALFLDLKTNSLEAIYKNIYKLLLLHALRFHVCAQSLPFGQSVAKNPAYFLLMIWDMVEYTNYLIRLSNNGLISGSTSQTGSVQYEAVELLFCLSFLLVLSKHRRLYKDLLLHLHKR 
Danio rerio           IKSTDIFLDLRLNSVEAVYRSLYKLILLQALRFHACVRSLPLGQSVNRNPSFFLKMIWRMTRVTNKLLTHINKGLPVCSVDSGGVLQSEAVQLLFCLAFETLFRRFRSVYHCLIPALHKR 
region                ------------region v-VI----------------------------------|  |-------------------------region v-VII---------------------- 

                              1330      1340      1350 
                      ....|....|....|....|....|....|...
motif                                   |E-IV|          
Homo sapiens          QTQLSRKLPGTTLTALEAAANPALPSDFKTILD 
Mesocricetus auratus  QKQLCRKLPRATMAILETAADPALSTDFQTILD 
Mus musculus          QKLLCRKLPEATMTILKAAADPALSTDFQTILD 
Rattus norvegicus     QKQLCRKLPEATMTLLKTAADPALSTDFQTILD 
Canis familiaris      KAHLSRQLPRGTLAALEAAADPSLTADFKTILD 
Bos taurus            RARLHRQLPGPTRAALEAAADPALTADFKTILD 
Coturnix japonica     KMHLFGKIPKDTMELLKTVTEPSLCQDFKTILD 
Gallus gallus         KMHLFGKIPRDTMELLKTVTEPSLCQDFKTILD 
Xenopus laevis        KMQLSRRLSQDTIELLKSVTDSSLHKDFSCIMD 
Oryzias latipes       KRRLERLLGDLRLARVRQAANPRALLDFLAMQM 
Oryzias melastigma    KRHMERLLGDLRLARVQQASDPRALLDFL--QM 
Epinephelus coioides  KRSLERRLGDLRLARVRQAAKPRTPNDFLAIQM 
Takifugu rubripes     KRRLEQCLGDLRLARVRQAANPRNPLDFLAIKT 
Danio rerio           KRALQRELCGITLARVRQASSPRIPLDFS-MRV 
region                --------------------------------|