10        20        30        40        50        60        70        80        90       100       110       120                    
                        ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
motif                                                                                                                                            
Ciona intestinalis      MKPVDWKIKTNCRAKFTSCEYVDIENSIKPMQHPSNMQSILPLHKIFYSKVSFNDKNNQDIFPTSHILMKLSKSKTGARDLVRHIFKDQNVENEIGKKRSRETDETLQEPVSKKRCVIDD 
Ciona savignyi          ------------------------------------MNLNIYVHTILYSKVSFNDKTNEEIFPRCHVLRKLSVSNTSARKLVQHIFKDIISESRTSVDKIIKKPAISQNLQLQKTSAVNT 
Apis mellifera          -------------------MMDNFTLQSLKKDFGTYFQQYCLHHKILIKKNKCNAFIVSNVCDLKKCIAAVNCLKFNINRKLKKLQTDALFINSLNPIYYIPKLDEQYKIQEKINRNDNQ 
Bombyx mori             ------------------------------------MNTPICFSKYFVDKYNLRSFDN--------VLKSKVFSYDDSTFCLYLLKSETSIS---------------------------- 
Bombyx mandarina        ------------------------------------MNTPICFSKYFVDKYNLRSFDN--------VLKSKVFNYDDSTFCLYLLKSETSIS---------------------------- 
Tribolium castaneum     ------------------------------------------------------------------------------------------------------------------------ 
Caenorhabditis elegans  ------------------------------------MAPTIKSSLTTLHEEIR------------------KYDK---RRHWNTIIRKS------------------------------- 
Caenorhabditis remanei  ------------------------------------MSPEYRLLFKFQKKYVIS---------------LAKLHKNLGENHWSTILREN------------------------------- 
region                                                                                                                                           

                                130       140       150       160       170       180       190       200       210       220       230       240           
                        ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
motif                                                                                                                                            
Ciona intestinalis      TDN-ATLKSELETEFVGSKLKQTDVVPMVKQANEKVLINKNDSSVAKSLFSSSFAKVFSMAHTIKLETLSHEFDSSLPSTADASDSKPTKRS----KFKAKRKQKPNLPRRLRKCIPLCY 
Ciona savignyi          TNFTDTSATLFEKTFAG---------------------FGFETKVKKKHVAFNGCNKLCKASSTYKENLS-KFQLAFTPDKIRIISEPE-------VFKTS-KDKLNILRRLRKCIPLCY 
Apis mellifera          DKQYKIKKK-------------------------------------------KNFHKEITYHNIFLNNLNLNIFLCNTSQILPYYTNYKSFSICILNIDKKGHEIYDFITKGNRKDAIAI 
Bombyx mori             ----------------------------------------------------SLTKELIQIFSLMKSNLKSKCKEDFTQYFNQLTQKVG--------LEEVDKEFIFKCSYQALCDIVPF 
Bombyx mandarina        ----------------------------------------------------SLTKELIKIFSLMKSNLKNKCKEDFTQYFNQLTQKVG--------LEEVDKEFIFKCSYQALCDIXPF 
Tribolium castaneum     ------------------------------------------------------MVHYYRLSLKSRQKAPKIVNSKYNSILNIALKN-----------------FRLCKKHKTKKPVQIL 
Caenorhabditis elegans  -------------------------------------------------------AHLSLVRNIFKKKRRQKLNYRHMSTFLASSENIS---------NIRDTVVLLEINKLSQSILSSR 
Caenorhabditis remanei  -------------------------------------------------------ANLAILRNIFKRKMKGKLNYRHMSAFLVSSENVL---------KVRNTVVMDEVDKLSKSIVSTR 
region                                                                                                                     |------------------re 

                                250       260       270       280       290       300       310       320       330       340       350       360           
                        ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
motif                     |-----------motif CP--------|                  |-------------------------------motif QFP------------------------------ 
Ciona intestinalis      NILKKTDNRKLFSCLSHYTKFISPFERSFAKKNLDLLMEISTIEL---TEHISKMLQHYTSTHQVFLYLRSALKKTFPIHLMWGTKHNRSVFLKNLEKFLSCRRFDKVTIADFTRGIVME 
Ciona savignyi          NLLKKTNNRTIFNKLTYYTKFKSSGERSLTKQDLHQLSKLPVTQL---TEHLSKMLQLYTTKHQVYLFLRASLKKTIPIHLMWGTKRNQTAFHKNLKQFLGCRRYDKFSILDFTKGLCIE 
Apis mellifera          NYEDYFLLIEKFQNRHKKFNYYSVLKHLICKQKYNEKTKCIYEINKKQLKNFFDLIFAKVVPKRLFGSITNLKKIKRATFQLLDTPCFKYFNLKPIIEKLDIINITWLQNVTNVKTKWLV 
Bombyx mori             NFFGNYENKKLFRCMVHDIIFSMKMQHLLPE------------------KYLKTWDFDILPWRNISYTILHKILLWLLTAILPSIICLTFYVTTCKLDSDENKLI--------------- 
Bombyx mandarina        NFFGNYENKKLFRCMVHDIIFSMKMQHLLPG------------------KYLKTWDFDILPWRNISFNILHKILLWLLTAILPSIICLTFYVTTCKLDSDENKLI--------------- 
Tribolium castaneum     ALLQEIIPKSYFGTTTNLKRFYKVVEKILTQSSF---------------ECIHLSVLHKCYDYDAIPWLQNVEPNLRPKLLLKHNLFLLDNIVKPII----------------------- 
Caenorhabditis elegans  NIFELRKLKPTRKMVEIEHCFVSKNDTFVACSKLIS-------------MFHLEKYIGSTNCANILEWITKMLNNGGYHKMKPFVYKEAPFTRAFRASKVMKNVDPNVKRNIQTSIV--- 
Caenorhabditis remanei  HNFELRKLAPKRKKKNSRDCYMFEHETMNIIRRVFT-------------IFRLRQHIGSTNCDSMLVWIMNIMKQEKLQYVPDFVFKEAPLARAFRAKQVLKDVDPLSKRYSQFSII--- 
region                  gion v-II--------------|                                            |--------------------------------------region v-III- 

                                370       380       390       400       410       420       430       440       450       460       470       480           
                        ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
motif                   ----|          |-------------------motif T------------------------|                  |-motif 1| |-2-|                    
Ciona intestinalis      DLPWLKGEDTSSNLLRFFQWMIEDYVFVVLSGSFYITENSNFKNRLFFYHKKMWAEIVAYGVALLLKQNRWAVPPIADVTIRPYFSVRFCPKVNG-LRPIMRLRNADKM----PDMVPFE 
Ciona savignyi          DLPWVKGIYGKDTLLQFFKWIIEEYLFVLIRGSFYITDNGNFKNRLFFYPKKIWSEAVAYGVALLLKQKRWAFHSSEKHTVPPYFAVRFCPKLNG-LRPIMKLRNPKEP----SSKMSFN 
Apis mellifera          MA-------------QFVKWFFTEFLFNILYTYFHITKVSGNTNERLYITRFTWNNIQKKFIKEGIHSNTLQPNIKRNTWNPSIGIYKLLCKYSD-VRPIFKLKKK------FRDTDYLF 
Bombyx mori             ---------------YFWKSQWQSFCDKKISKMLFSNVMEKFEPYCLGKKIKRNLPIAKRLDLKKLIKEVP--------------KLHLVLKPNYDCRPIVKYRNDELNKRQKYRIKEKL 
Bombyx mandarina        ---------------YFWKSQWQSFCDKKISKMLFSNVMEKFEPYCLGKKVKRNLPIAKRLDLKKLIKEVP--------------KLHLVLKPNYDCRPIVKYRNDELNKRQKYRIKEKL 
Tribolium castaneum     ---------------AFYYKPIKTLNGHEIKFIRKEEYISFESKVFHKLKKMKYLVEVQDEVKPRG-------------------VLNIIPKQDN-FRAIVSIFP----------DSARK 
Caenorhabditis elegans  ---------------NNLKSGVHWWALMALRQVMIPIVIKEERVLLWRDGYLNILTKEIKDFKQRYIVQKAPH-----FIRPNVATFKLSISRQK-LRPLFKRKA--------IDKKTET 
Caenorhabditis remanei  ---------------NHLRGALIWWIFAALRQIMIPIDVKRKKVYLWRGGYLKLLRREMKDFKERYKVKRKPAFVLNPSPNSVVGRLKFDIVENK-FRPIIRRNP--------IDKVKDK 
region                  ---------------------------|   |-------------------region v-IV------------------|                                        

                                490       500       510       520       530       540       550       560       570       580       590       600           
                        ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
motif                                                                |---------motif A------------|                                              
Ciona intestinalis      VIASVLKLVCSKVPQATGFATQHHAHIYNGWKLFVLSLAGIP-GRKRLFFVKMDIHRCFDSIPVVKLILIVEGLLDRSGEVDLTSATKGKLN---------------------------- 
Ciona savignyi          SISSVLKLALQRFPDSLGFAIKDRSDIYCKWRQFLLKLKEINAKRWQLYFVKLDICRCFDSIPIPKLLRIVQDLLDRAGTLDVSIVTKGKLR---------------------------- 
Apis mellifera          IIFKFLKQLYVTNYEVINFPKKWKSIVQKLNSKT-----------EKLYFVCCDVINAFGSIIQVELYNIIQSLCKDLPENLILKYYTMKSE---ISKKDNTYHKYFSDLQLPFPSDQFY 
Bombyx mori             QLLKLLTGNQQHKIETAYPKLHSKWLELNK---------------PKLYFIKTDLSDAFGSINTDKMMKILHENYLNYHKTES------------------------------------- 
Bombyx mandarina        QLLKLLTGNQHHKIETAYPKLHSKWLELNK---------------PKLYFIKTDLSNAFGSINTDKMMKILHENHLNYHKTES------------------------------------- 
Tribolium castaneum     PFFKLLTSKIYKVLEEKYKTSGSLYTCWSEFTQKT---------QGQIYGIKVDIRDAYGNVKIPVLCKLIQSIP--------------------------------------------- 
Caenorhabditis elegans  MQWKRLNSMLSWCLERSGVYRHTIRDSCKKVSDFLKKNS----QNSKIIGYTADVSKCFSTVNHDVLISIIDRLFSQEHDIYTVCGKGRNHGGFHKLIFCSAGTELNAHEALRRKMELKG 
Caenorhabditis remanei  MHWKKVNSMLTWCLEKGGETRQSINSSCKILLKFLRRND----TFPKLFGYTADVSKCFSAVKHSTLTSIIERLLDIW-----TACGKGRDKKGFHKLIFCSNDSEEGAYQSLKKKMESK 
region                                                                                                                                           

                                610       620       630       640       650       660       670       680       690       700       710       720           
                        ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
motif                                                      |-------------motif B------------|          |----motif C----| |----------motif D----- 
Ciona intestinalis      -------CKVKHCTHCILTTLKYFLNKVTLSVLSKKFVKLHGIPQGWELSNLLCDIFYGHMEQQHLINVLDPIDGEPHLILRYVDDYLFVTTSRYK-ANAFLKLMYSDNFKEYGFIVNTK 
Ciona savignyi          -------CKIHHCSQYIVDQLKFFLRDVTLSVLSKTFIKLNGIPQGWLLSSLLCNIFYGHMEQTHLFKVFEGINHEPCLLLRYVDDYLFITTNQDK-ATTFLQLMHSG-FEDYGCKINPK 
Apis mellifera          ANLVDNQWYQLINKSWLLESISKYIFYQRIKINKNIHIIGKGIVQGSMLSPILSDIYYNYILNKEMSTYLKTGE-----IIKYMDDILYITENKTL-AEQFLELTKKG-IPQYNCYFKQS 
Bombyx mori             -----NMVLKKRVSEQFRNLVAELRKPLLVRFGSTIFRWKEGLVQGYKYSPALSELYYSYMDKKYLTEHLKVDNRKIKMFFRVVDDYLYITDCFDD-AIAFLSKISNY------RNVNYS 
Bombyx mandarina        -----NMVLKKRVSEQFRNLVAELRKPLLVRFGSTIFRWKEGLVQGYKYSPALSELYYSYMDKIYLTEHLKVDNRNIKMFFRVVDDYLYITDCFDD-AKAFLSKILNY------RNVNYS 
Tribolium castaneum     ---------THLLDSEKKNFIVDHISNQFVAFRRKIYKWNHGLLQGDPLSGCLCELYMAFMDRLYFSNLDKD-----AFIHRTVDDYFFCSPHPHKVYDFELLIKGVY-------QVNPT 
Caenorhabditis elegans  VFNFEVCYREMSSSTTLYSVIRTTLSTYYYKRGPTSWRITKGVPQGHPISSNLAHMYLNNFEQKYWSNEKED---SRIVFCRYEDDFIFITTENSL-FEKMMKPLSTGNNTHF-----LT 
Caenorhabditis remanei  HVEDHTVIYCNVCSKWLLDQLRSTISSYCYKRGKTTFKITKGVPQGHPLSPNFAFMYLNDFEKENWRKVEHD---ARIIYCRYVDDYVFMMTDKDL-FKQISQPLFTGKNQHGVKANYEK 
region                                                                                                                                           

                                730       740       750       760       770       780       790       800       810       820       830       840           
                        ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
motif                   -----|              |---motif E---||-----------------------------------------------motif E-I---------------------------- 
Ciona intestinalis      KTCTNFAS-DCSQQLEDLQEQDTFPWFGYLFPTCL-----NMGRKQLKQKGTHNFGGVSVDLSAYQSTHCIRDFISVQSPGTYNYFQQIRRNLTRRVTEICFDPQIN-------GKMRIY 
Ciona savignyi          KTCINFHPNFIDSQVLILNNEEPFHWFGYIFPTCI-----NMNKKQIKQTGTNNFGGISMDLSSYQSTRRYRDFMSTRSSVTIYRQCSIQKNMTRRVDHMLFDPQIT-------CRKRIF 
Apis mellifera          KTQSNLIS------DRNKIVKKNIIYIGYKINCTT--------------------LEIELKRSDTALCHSISFLKPSKLSLLKHLSMRLSNVATFRLSKVMLDHTIN-------SKKTIM 
Bombyx mori             KTAVNFQHPSIRY-------SEDITFIGYSYNTVTLEVSRVNSIFYGQICYKINFTSAVENISKFIENRIGQSGIQISSHLFNLQYNSEELIWKHVFTTFCFSGNKFCTILAIACCEKDM 
Bombyx mandarina        KTAINFQHPSIQY-------SENITFIGYSYNTVTLEVSRVNSIFYGQICYKIKFTNAIENISNFIENRIGQSSIQISSHLFNLQYNSEELIWKHVFTTFCFSGNKFCTILAIACCEKDM 
Tribolium castaneum     KTRTNLPTHRHP--------QDEIPYCGKIFNLTT--------RQVRTLYKLPPNYEIRHKFKLWNFNNQISDDNPARFLQKAMDFPFICNSFTKFEFNTVFNDQRT-------VFANFY 
Caenorhabditis elegans  ANPKKFKKSERCGA------SQVLQWCGVKLDFQS---------------------------------------------------------------GNCFIRRR--------CKDGVA 
Caenorhabditis remanei  CKVLTFQES-----------DDKLIWCGVKMDLKN---------------------------------------------------------------AKFYRRKR--------CLDGTI 
region                                                                         |-----region v-V-----|   |-----------------------region v-VI----- 

                                850       860       870       880       890       900       910       920       930       940       950       960           
                        ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
motif                   ------------------------|       |------motif E-II--------|      |---------motif E-III-----------|                      | 
Ciona intestinalis      RNLY----ELAMLGAIQMVAHQLHEGQPWVIGNPWQFRSNIKQMANAVLARIQRVFKSKHFLTRPLVSWLFYKAFKTKMKRHSNNKAALPVLQMGINQCVHQLCEVGEWDNVRHYLQRAV 
Ciona savignyi          RNLY----EIALLGAIHTVAYDLHRKD--IYKDPLIINIFINLVAHRVWVIIQRKFKGKHFLSNSLVKWIFFKAFLVKLKRHHYYKKVIPSLHRQVLLNTTRLQNSKKWRENRFKMREAL 
Apis mellifera          RILK----EVCVLQANRA-------------------CILIKDLFDNVHNHIQNIFKIIKSTNEKITRYIIRMFLISQQKTSKLKIYKWNNQILHILWTSYKKVFMKDNILRQYFITFFS 
Bombyx mori             KNYLPLYKKRVTVRITNAILANLMMAKPKLIEFVYCINHFRYLSWLALYYNAQKTWKCSNLIPLIKIELAKSNCLFGKWREHARFISSNGDVQNHAIKEICRRSDLRAIVKKMDRLPYGF 
Bombyx mandarina        KNYLPLYKKRVTVRITNAILENLMMAKPKLIEFVYCINHFRYLSWLALYYNAQKTWKCSNLIPLIKVELAKSNCLFGKWREHARFISSNGDVQNTAIREICRRSDLRAIVKKMDRLPYGF 
Tribolium castaneum     DAMICVAYKFDAAMMALRTSFLVNDFGFIWLVLSSTVRAYASRAFKKIVTYKGGKYRKVTFQCLKSIAWRAFLAVLKRRTEIYKGLIDRIKSREKLTMKFHDGEVDASYFCKLPEKFRFV 
Caenorhabditis elegans  RQFL--------IKLQ-------------------------------------------------------------------------------------------------------- 
Caenorhabditis remanei  RDHLI------------------------------------------------------------------------------------------------------------------- 
region                  -------------------------------------------|  |-----------------------------------------region v-VII-------------------- 

                                970 
                        ....|....|....
motif                   E-IV|          
Ciona intestinalis      GMFPIHYRKVNCGL 
Ciona savignyi          INFPVTLCKLKT-- 
Apis mellifera          -------------- 
Bombyx mori             EVYNKKKF------ 
Bombyx mandarina        EVYNKKKF------ 
Tribolium castaneum     KINRKASI------ 
Caenorhabditis elegans  -------------- 
Caenorhabditis remanei  -------------- 
region                  -------------|