10        20        30        40        50        60        70        80        90       100       110       120                    
                            ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
structures                                                                                                                                           
Schizosaccharomyces pombe   ---------------------------------------MTEHHTPKSRILRFLENQYVYLCTLNDYVQLVLRGSPASSYSNICER-------------LRSDVQTSFSIFLHSTVVGFD 
Saccharomyces cerevisiae    ------------------------------------------------------------MKILFEFIQDKLDIDLQTNSTYKE--------------NLKCGHFNGLDEILTTCFALPN 
Saccharomyces paradoxus     ------------------------------------------------------------MRSLYEFTQDKLNIDLETCIIYQE--------------NFKCGQFNGLDEILTTCFILQN 
Saccharomyces mikatae       ------------------------------------------------------------MKSLYDFIQDKLEIELETNITYEE--------------NIESGQFNGLDEILTTCFILQN 
Saccharomyces kudriavzevii  ------------------------------------------------------------MKSLYEFIQDKLGTDFESNALNQD--------------NFECGQFNGLDELLTTCFILPN 
Saccharomyces bayanus       ------------------------------------------------------------MISLSEFIHDKLNTDLETNALHHD--------------VLKYGQFNGLNELLTTCFILPN 
Kluyveromyces lactis        ------------------------------------------------------------MKILVEYLES---LECYETLRKSD--------------ILINADSNGVSNLLLSCFAQVN 
Candida albicans 1          ------------------------------------------------------------MTVKVNEKKTLLQYVLDNTSNDVP--------------LLPS-----LKEYMETVLVYKS 
Candida albicans 2          ------------------------------------------------------------MTVKVNEKKTLLQYVLDNTSNEVP--------------LLPS-----LKEYMETVLVYQS 
Ashbya gossypii             MSFKEKRK--------------------LEATDASSDRKRVRTSRDTLVKRDLLDRCYDKVTTLREYILLKLPPRSRLRRKKVASVGE---------GDDVGELESNLSRLLDTSLVCFD 
Aspergillus fumigatus       MGQKRKRPVKDGCAAD-----NSALRRIISASSGSRNHGASARNEKDGHSHPVISLYYRQVVTLRQYLLQQIPVTSKSRRRRIASIRSDPLTQREGDDSPGDRQVQDLASVLDTTLVGVL 
Aspergillus clavatus        MGKKRKRPSKDSGAGE-----DLAQKRLAGGPNGVRSHHATDAYEGSGHSHPVISLYYHRVVTLRQYLLQQIPVSSKSRRRRITSVQGATSTEKQKNRGVRGYHAQGLADILDTTLVGVL 
Aspergillus nidulans        MGKKRKRPVKEPVKDDPICRAKSSPQQPAGNTARSLSTNRNQAADAGKICHPVISLYYRHVVTLRQYILQRIPRSSRARRRRIAAVGG--HSAARDGLAAVPKNEKDLADLLDTTLVGIL 
Neosartorya fischeri        MGKKRKRPIKDGCTAD-----NSAPRRIISTSGGSRNHGASARKEKDGHSHPVISLYYRQVVTLRQYLLQQIPVTSKSRRRRIASIRSDPLTQSQGDDSSGERQVQDLASVLDTTLVGVL 
Encephalitozoon cuniculi    ----------------------------------------------------------MKIYKSRQMLELLKSFGFLSLRDFLAAYG-----------------VADLPDIVDRVYVRAS 

                                    130       140       150       160       170       180       190       200       210       220       230       240           
                            ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
structures                                                                                                                                           
Schizosaccharomyces pombe   SKP-------------------------DEGVQFSSPKCSQSELIANVVKQMFDESFE---RRRNLLMKGFSMNHEDFR----AMHVNGVQNDLVSTFPNYLISILESKNWQLLLEIIG- 
Saccharomyces cerevisiae    SR--------------------------KIALPCLPGDLSHKAVIDHCIIYLLTGEL-----YNNVLTFGYKIARNED-----------VNNSLFCHSANVNVTLLKGAAWKMFHSLVG- 
Saccharomyces paradoxus     SR--------------------------KVALPYLPGDLSHKAVIDHCIIYLLTGEF-----YNNVLTFGYKIARNED-----------VDNSLFCHSANVNVTLLKGVPWEMFHSLIG- 
Saccharomyces mikatae       SR--------------------------KIALPSVSGDLNHKAIIDHCIVYLLTGEF-----FNNVLTFGYKIAKNED-----------VDNSLFCHSTNVSVTLLKGTAWKMLHNLIG- 
Saccharomyces kudriavzevii  SR--------------------------KIALPSISGDLNHKSVVDQCITYLLSGDF-----FNNVLTFGYRIARNEN-----------VNNSLFCHSTNVSVTLLKSTTWRMFHDLIG- 
Saccharomyces bayanus       SR--------------------------KIALPSIAGDLNHKSVIDQCIIHLLTGDF-----FNNVLTFGYRIARNEN-----------VDNSLFCHSTNVSATLLKSSTWELLHGLIG- 
Kluyveromyces lactis        SKH---------------------CVPPEIEISSTFSSSYHCETIETCILYLLHKNF-----TNNILTYGYQLGKNSD-----------VMTKLFCRSSNISVSVLKCNSWRLFHQLVG- 
Candida albicans 1          IKR---------------------------PLPAIRPQESFDEFMKELVTRLVMEK------SNNVIAYGYKTSAMESR----------SIFTTFHSSGNFILTHITSHNWSTIFSLLG- 
Candida albicans 2          IKR---------------------------PLPAIRPQESFDEFMKELVTRLVMEK------SNNVIAYGYKTSAMESR----------SIFTTFHSSGNFILTHITSHNWSTIFSLLG- 
Ashbya gossypii             NDQQNVKDVDMRKKQLIEFTQKGDESYVSLSDGISGSVFSQDEIMDFVVWLLFQRE--PHARPKHILCDGFQKLAGQN------GQGTTNIPDLSIRHHNSHVKALRESPWPQLLALLG- 
Aspergillus fumigatus       NET-SPTVTQERRRDFAAYSQTQSQCRSELTSTDTGPPCSQSEIVDFVITSLFNRNGFSYHRPQHLLAHGYQRAGASERMTDNLAAPTSSIPGLVVRFPNRNVETLKHAPWTNVLALLG- 
Aspergillus clavatus        KES-SPTVTQERLRDFASYSQSQSQGRSEVPSTDVGPPCAQSEIVDFVISALFNRHAFSYQKPQHLLTHGFQRAGGPD------VKLASSIPGLARRYPNKNVQCLKQAPWTDVLGLLG- 
Aspergillus nidulans        KEL-PPTRSEERRRDFIAFTQAQQTTQT---GTDSGP------IVDFAISSIFNRP--SHGKLENVLSHGYRQG---------GGRLPCSIPNVAAQFPNKNVQMLKQSPWTEVLALLG- 
Neosartorya fischeri        NET-SPAVTQERRREFAAYSQTQSQCRSELTSTDTGPPCPQSEIVDFVITSLFNRNGFSYHRPQHLLAHGYQRVGAPERMTDNHAAPTSSIPGLVVRFPNRNVETLKHEPWTNVLALLG- 
Encephalitozoon cuniculi    RTP---------------------------VVSSFKSTQKDVELISKAVRTLLIKNR------DNHLCAGYKWWSPGLPG---------ASTKIICYFPNSSSRILRSHEWSWLMRSIGD 

                                    250       260       270       280       290       300       310       320       330       340       350       360           
                            ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
structures                                                                                                                                           
Schizosaccharomyces pombe   SDA---MHYLLSKGS--IFEALPNDNYLQISGIPLFKNNVFEET--------------------------------------------------------VSKKRKRTIETSITQNKSAR 
Saccharomyces cerevisiae    TYA---FVDLLINY---TVIQFNGQFFTQIVGNRCNEPHLPPK----------------------------------------------------------------------------- 
Saccharomyces paradoxus     TNS---FVDLLINY---TVVQFNGQFFAQIVGNRCNEPHLPPK----------------------------------------------------------------------------- 
Saccharomyces mikatae       TNA---FVDMLINH---TVIQFNGHFFTQIIGNRCNEPHLPPK----------------------------------------------------------------------------- 
Saccharomyces kudriavzevii  TYA---FVDILVNY---TVIQFNGQFFSQIVGNKCNEPHLPPK----------------------------------------------------------------------------- 
Saccharomyces bayanus       THA---FVDLLINY---TVVQFNGKFFTQIVGNRCNEPHLPPK----------------------------------------------------------------------------- 
Kluyveromyces lactis        TDN---FVNLLINY---SVYFNTGHYFRQIIGTPANAPQVPPA----------------------------------------------------------------------------- 
Candida albicans 1          PKK---FLELLVN---------NKGFVSKVNGE--SVQIFGDV----------------------------------------------------------------------------- 
Candida albicans 2          PKK---FLELLVN---------NKGFVSKVNGE--SVQIFGDV----------------------------------------------------------------------------- 
Ashbya gossypii             KAGEEIMIKLLVDASIYVAVEAGLNNYHQLSGVPLAELD---------------------------------------------LPGGNVSLNKGSAPSDSSNLDAGS------------ 
Aspergillus fumigatus       GNGEEIMLRLLLDCGIFTAIDHRKGIYYQLSGLPLSSLEPVKR---QLPQEVSDLSGASIKTANNTGGFCSGPQHRKSVRQEVVHKPNSIVFFRRRMLYAKPVLNSKGDVHFGLTRLHVL 
Aspergillus clavatus        GNGEEIMLRLLFDCGIFMAIDHRKGIYYQISGLPLSSLEPIQN---QSPLEVPNANSKPSLAAGSN-----VARKNRSSDQGIAHKPNSVVFFRRRMLYAKPILNSRGEVHFGLSALHVL 
Aspergillus nidulans        SNGDEIMLKLLLDCGLFMAVDARKGVYCQISGQAISSLKPIDTSPEDCPAAFNGSSSPVKRHAVPWQGAAPRAHTKGPKENQQQLSPNAIIFCRQRMLYARPHLNANGGITFGLPN-HVL 
Neosartorya fischeri        GNGEEIMLRLLLDCGIFTAIDHRKGIYYQISGLPLSSLEPVKR---ELPQEVSDLSGASIHTANSTGGFCSGLKKRKSVRQEVVHKPNSIVFFRRRMLYAKPVLNSKGDVHFGLTRLHVL 
Encephalitozoon cuniculi    ELAFFILTECLVIQMLNSGYVFLAGDFKSLSGMATER----------------------------------------------------------------------------------- 

                                    370       380       390       400       410       420       430       440       450       460       470       480           
                            ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
structures                                                                                                                                           
Schizosaccharomyces pombe   KEVSWNSISISRFSIFYRSSYKKFKQDLYFNLHSICDRNTVHMWLQWIFPRQFGLINAFQVKQLHKVIP--------LVSQSTVVPKRLLKVYPLIEQTAKRLHRISLSKVYNHYCPYID 
Saccharomyces cerevisiae    --WAQRSSSSSATAAQIKQLTEPVTNKQFLHKLNINSSSFFPYSKILPSSSSIKKLTDLREAIFP-------------TNLVKIPQRLKIRMNLTLQKLLKRHKRLNYVSILNSICPPLE 
Saccharomyces paradoxus     --WAQRTS--SGNTAQIKQLMGPVTNKPFLHRLKINSPSFFPYGKILPLSSSFKKLTDVRETIFP-------------INLVKIPQRLKVRINLTLQKLLKRHKRLNYVSVLNSICSPSE 
Saccharomyces mikatae       --WAQRSSPSSGSIAQIEPVMEPVTNKPFLHKLKLNCPFIFPYKTILSLSSSIEKLIELRENIFP-------------SYLVKIPQKLEVQINLTLQKLLIRHKRLSYVSILNGICPRLK 
Saccharomyces kudriavzevii  --WAQRASSSSERTVQMKQLTRPVTNKSFLHKLKTNSSTFFPYGRILSSSSSINRLSELREAIFP-------------SNLIKVPQRLKIGIDLTLRKMLTRHKGLNYVSILNNICPPLI 
Saccharomyces bayanus       --WVKKSSSPSDTTLLMKQLMEPITNKPFLHRLKINSPNFFPYGRILPSSSTLNKLTELRDAVFP-------------PNLVKIPQSLRIRVNITLQKLLTRHKRLNYVSILNNICPQLK 
Kluyveromyces lactis        --WLDRSYRRERNTKLTIDWNSALYHKIRPQDYKN----IIETDQGLLIAEIFPKISESSKTPRS-------------LNFALN------NLKPILYELIRAHERFSYRHIINNICPKSD 
Candida albicans 1          --NSHRKAVVVSKYITKFNVLYNSYSRDFSRFEMIRPSIQTILQDILSFSGLNPGRSSKRYRGFK-------------SLLSRIIANDKKCRYDILYAKFIGTSKCNFANVVS------- 
Candida albicans 2          --NSHRKAVVVSKYITKFNVLYNSYSRDFSRFEMIRPSIQTILQDILSFSGLNPGRSSKRYRGFK-------------SLLSRIIANDKKCRYDILYAKFIGTSKCNFANVVS------- 
Ashbya gossypii             ---------HGVIKIMMYMFPRQFGLHNVFTFQVDHTKTSQKFQDYTSREEEIAPIFQAKPGDAASRKP-------------KIPKRLRGDVEQLVKRLQILHSRCSYTELLSYYCSCVF 
Aspergillus fumigatus       NRYPRSDSLSETVHILKYIFPRQYGLHNVFTSVTDSRETVMPFKDYFSRETEIAQMDEQKRKRRQRIGPGFMNHFEKHKDLVEIPKRLRGKAVELVQQLQNRNRRCPYVKLLDYYCPADD 
Aspergillus clavatus        NRYPRSDSLSQTVHILKYIFPRQFGLHNVFTSVTDSRETVLPFKDYFSRETEIEEIEEKRRKQRRRIGPEFTNHYQDQKEFIDIPKRLRGKACELVQQLQNRNRRCPYTELLNYYCPPVD 
Aspergillus nidulans        SRFHSAKSLQQTVHVMKYVFPRQFGLHNVFTSHSSYYENPLS-KNYSSREEEIARKEGLEAARNQLRKSGFHAAIGERQESIKIPKRLRGKPLELIRQLQNRSRRCCYKKLLQYYCSEEL 
Neosartorya fischeri        NCYPRSDSLSETVHILKYIFPRQYGLHNVFTSVTDSRETVLPFKDYFSRETEIAQIDEQKRKRRQRIGPGFTNHFEKHNDLIEIPKRLRGKAVELVQQLQNRNRRCPYVKLLDYYCPIED 
Encephalitozoon cuniculi    -------------------VSNAIGRNVLFYKETRRISFCSLSAFEYVFEAHNSEKYKVIQKDAR----------------------------DVLESIERRWKKISTHAIFKSFFKDEL 

                                    490       500       510       520       530       540       550       560       570       580       590       600           
                            ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
structures                                                                                                                                           
Schizosaccharomyces pombe   T------------------------------------------------------------------HDDEKILSYSLKPNQVFAFLRSILVRVFPKLIWG----NQRIFEIILKDLETF 
Saccharomyces cerevisiae    G-----------------------------------------------------------------TVLDLSHLSRQSPKERVLKFIIVILQKLLPQEMFG----SKKNKGKIIKNLNLL 
Saccharomyces paradoxus     E-----------------------------------------------------------------TVSNLSHLSRQSPKEQVLRFIIVILQKLLPQEMFG----SKKNKCKIIRNLNLL 
Saccharomyces mikatae       E-----------------------------------------------------------------TTSELPHLSRQSPKEEVLKFVIVILQKLLPQEMFG----SKKNKCKIIKNLNSL 
Saccharomyces kudriavzevii  E-----------------------------------------------------------------NGSELSHLGWQLPKEQVLRFLIVILEKLLPKEMFG----SKKNKCKIIRNLNSL 
Saccharomyces bayanus       E-----------------------------------------------------------------NASELPHLKSQLPQSQVLKFLIVILQKLLPQEMFG----SKRNKCKIIQNLNSL 
Kluyveromyces lactis        --------------------------------------------------------------------------TFYSSPKSVIKLLIVCVRKTFPLDLLG----SNSNYSVLSKAIAIL 
Candida albicans 1          ---------------------------------------------------------------------------NKTEISQVIQFVLLVLGKLLPLDAWG----GVSNKKIIKDRVVDF 
Candida albicans 2          ---------------------------------------------------------------------------NKTEISQVIQFVLLVLGKLLPLDAWG----GVSNKKIIKDRVVDF 
Ashbya gossypii             DRPSQIRKPKAKKIPMSTRKPKPSQHPFS--RSNQKCVSSQMHPEAGTSG-----------TQVQSLPEHDSLVELATPSFQVSSFCRAVLSKIIPDSFWGDKDAGKHNKSIAMRNVDHF 
Aspergillus fumigatus       VWPWKLSHTNSQEGSTGEEPRTPSDRLVTQPRGAEQHAARDVGPKESPKIRYSTHDTEDGTTKCLVPEPKQNLMDYATPSSSVSAFCRAVLRKLIPPQFYGIGQYQKSNQEIIFSHVDRF 
Aspergillus clavatus        TGPWKLGPTDSQTSHPSG--TAISESLVTQRRGPQGSFAHAS-PLSHLQETPSVATFKAEATVSKILKPKLCLIDYATPCSSVSAFCRAALRKLVPPRFYGTGCHQRSNQDIVFRHVDRF 
Aspergillus nidulans        SGPWILGQLSAESNSVLS--TSSSRPLVTQPSLAHQDMQRELRPTSYAKG---------FSKGSGATKPKENLTDHATPAASVSAFCRAVIRNLIPLEFFGVGEQGITHQKMILGHVDRF 
Neosartorya fischeri        VGPWKLGHTNSQEGSTGKGSCTASDQLVTQPRGAQQHAARDMGPKESLRTRNSIHDTEKGITKCVIPEPKQSLMDYATPSSSVSAFCRAVLRKLIPPQFYGIGQYQKSNQEIVFSHVDRF 
Encephalitozoon cuniculi    AIE-----------------------------------------------------------------DKSSALECGVKQSKLVNFLFLISKKLFKDAFDL------HGFRILKSRLSLL 

                                    610       620       630       640       650       660       670       680       690       700       710       720           
                            ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
structures                                                                             |-----------------------Motif T-----------------|         |-- 
Schizosaccharomyces pombe   LKLSRYESFSLHYLMSNIKISEIEWLVLGKR------SNAKMCLSDFEKRKQIFAEFIYWLYNSFIIPILQSFFYITESSDLRN-RTVYFRKDIWKLLCRPFITSMKMEAFEKIN-ENNV 
Saccharomyces cerevisiae    LSLPLNGYLPFDSLLKKLRLKDFRWLFISDI---------WFTKHNFENLNQLAICFISWLFRQLIPKIIQTFFYCTEISSTVT--IVYFRHDTWNKLITPFIVEYFKTYLVENN-VCRN 
Saccharomyces paradoxus     LSLPLNGYLPFDSLLKKLRLKDFRWLLVSDV---------SFTKQNFENLNQLVTCFISWLFRHLFPKIIQTFFYCTEISSTVT--IVYFRHDIWNKLVTPFLAGYFKKYLVENN-VCRN 
Saccharomyces mikatae       LSLPLNGYLPFDSLLKKLKFKDFRWLMVSTI---------SFTRQNFENLNQMVICFVSWLFRQLLPKVIQTFFYCTEISSTVK--IVYFRHDVWNGLVSPFLTGYFKRYLVENN-VCRN 
Saccharomyces kudriavzevii  LSLPLHGCLPFNSLMKNLRLKDFKWLLVSDS---------SFTKQNFENSNQLVIYFVSWLFRQLIPKIIQTFFYCTEISSTVA--IVFFRHDILDKLVAPFLREYFEKYLIENS-ICRN 
Saccharomyces bayanus       LGLPLNGHLLFGDLLKKLRLKDFQWLMVSDV---------SFTKQNFENSNLLMTFFVSWLFRHLVPKIIQTFFYCTEISSTVT--IIFFRHDTWNKLVTPFLAEYSEKYLTENI-VCRN 
Kluyveromyces lactis        VKKPLHSKILFDELCKGLRVKDVKWLETRRLPAGEQT--QKIPYYDVKNRQALLYKLFFWILSCYVPKLLSTFFYVTELSSTVD--IVYIRHDTWKTMSQPFLKSYFRRYLLENK-YCFQ 
Candida albicans 1          LLLGANEKIHMDDLFRGIRLKDFKWLGRAHQ---------ISSKQDFELRTAFLKGYLWWLFEHLLKNILRSFWYITETSSIVSSELNYFPQYLWKELYESWVSKYAKNNLVKMP-SKIQ 
Candida albicans 2          LLLGANEKIHMDDLFRGIRLKDFKWLGRAHQ---------ISSKQDFELRTAFLKGYLWWLFEHLLKNILRSFWYITETSSIVSLELNYFPQYLWKELYESWVSKYAKNNLVKMP-SKIQ 
Ashbya gossypii             IRLRRFETMSLHELTQDLKIAEISWL------QPHNTGTQKPSRTDTEKRLEIFHEFLYFVFDSLLIPLIRNNFYVTESNTHRY-RVFYFRHEVWRRIAEPAMADLKADMFEEVKLDDAL 
Aspergillus fumigatus       IRMRRFESLSLHEVCKGIKITSIPWLDYSRHQHQESLPGRKLSLSDLHKRTELLHEFIYYIFDSILIPLIRSNFYVTESQIYRN-QLFYFRHDVWRHLTLQPLATFKTTLFEEMKRADAE 
Aspergillus clavatus        VRMRRFESLSLHEVCKGIKITCMPWLGHPANQQDEGSSQPKMSLSDLRKRTELLHEFIYYIFESILVPLIRSNFYVTESQSHRN-RLFYFRHDVWRQLTQQPLAEFKTSLFEEMKRGVAE 
Aspergillus nidulans        IRMRRFESLSLHEVCEGIKPE----------SLRQAPSENNISASDLQKRRELFHEFLYYLFDSILLPLIRGSFYVTESQVHRY-RLFYFRHDVWRRLTAQPLAHLRASIFEELAPETAE 
Neosartorya fischeri        IRMRRFESLSLHEVCKGIKITSIPWL-----EHQESLPGRKLSLSDLHKRTELLHEFIYYIFDSILVPLIRSNFYVTESQIYRN-QLFYFRHDVWRHLTLQPLATFKATLFEEMKRADAE 
Encephalitozoon cuniculi    IHRNRYETVSKNELVKYFRISRFKFFR-----------TLRCTRSEFVFRFRVSSRFLVYITEKLIIPIISKYFYCTETSFSKF-KVHYFPRSIWRHFSSIHIDRFLEKFEPAKG----- 

                                    730       740       750       760       770       780       790       800       810       820       830       840           
                            ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
structures                  ------Motif 1---------| |-----------Motif 2-------------------|                                               |--------- 
Schizosaccharomyces pombe   RMDTQKTTLPPAVIRLLPKKNT--FRLITNLRKRFLIK---------QMGSNKKMLVSTNQTLRPVAS-------ILKHLINEESSGIPFNLEVYMKLLTFKKDLLKHRMFG---RKKYF 
Saccharomyces cerevisiae    HNSYTLSNFNHSKMRIIPKKSNNEFRIIAIPCRG------------ADEEEFTIYKENHKNAIQPT----QKILEYLRNKRPTSFTKIYSPTQIADRIKEFKQRLLKKFNN--ALPELYF 
Saccharomyces paradoxus     HNSYTLSNFNHSKMRIIPKKNNNEFRIIAIPCGG------------ADEEEFMIYKENHKNAVAPT----QKVLEYLRNKRQTSFTKMYSPMQIADRIKEFKQSLLKKFNN--VLPELYF 
Saccharomyces mikatae       HNSYTLSNFNHSRMRVIPKKSNNEFRIIAIPCGG------------ADDEEYMIYKENHKNAVAPT----QKILEYLRNKRLTSFTKIYSPTQIADRIKEFKLSLLKKFNN--VLPELYF 
Saccharomyces kudriavzevii  HNSYTLSNFNHCRMRIIPKKSNNEFRIIAIPCEG------------ADEEEFMVYKENHKRVIAPT----QKILEYLRNKRPTDFVKIYSPTQIADRIKEFKQGLLKKFNN--VLPELYF 
Saccharomyces bayanus       HNSYTLSNFNHSRMRIIPKKSNNEFRIIAIPCRG------------ADEEEFAVYKENHKKAVTPT----QKILEYLRKKRPTSFTKIYSPTQISDHIEKFKQILLKKFDN--ILPALYF 
Kluyveromyces lactis        HRSFTESKFNHRNLRLIPKKSGLDFRIIAVPCKG------------VNIQEFNEFNDYVTNALKPT----KIILERLRMRRNTKFTKAFSPLEIPKIVLSYKQRLLLKHG---KIPNLYL 
Candida albicans 1          R-----EQLPCGKIKLIPKRSS--FRVICVPIKRSLKLLNKKLELDTLEKEKREFERYRKEVLSPVGQILRLKLSKLRDTYESYRASVHSSSDVAEKISDYRDSLLTRFG---EIPKLFI 
Candida albicans 2          R-----EQLPCGKIKLIPKRSS--FRVICVPIKRSLKLLNKKLELDTLEKEKREFERYRKEVLSPVGQILRLKLSKLRDTYESYRASVHSSSDVAEKISDYRDSLLTRFG---EIPKLFI 
Ashbya gossypii             QILESR-DLGSSQIRLLPKGNR--LRPIMNLRRRAMAR----------G-QSRKLGLSINTVLGPIHS---LLKLER----------------------AFKGTLGPD------PGKLYF 
Aspergillus fumigatus       RRLCGR-SLGYSSLRLLPKTTG--VRPILNLRRRNLQP-------GWAG-KAPFLGPSINSTMTPIFN---VLKYETARNPASLGSTLSFVGEIHTRLKSFKERLSQS-HSSDRRKRLYF 
Aspergillus clavatus        RRLSSR-SLGYSSLRLLPKTTG--VRPILNLRRRMLKP-------GWAG-KAPFLGPSINSTIAPVFN---VLNYEKRRNPDSLGAALSFVGEIHTRLKGFKERLTQK-HAGHPRPHLYF 
Aspergillus nidulans        KLLSGKKSIGYGSLRLLPKTTG--IRPILNLRRRTLVRS------IYAGKNRYHPAQSVNSAIAPVYS---MLNYERGRRNDLLGSSMFSVGDMHSRLKKFKESLMSR--GWDQRKRLYF 
Neosartorya fischeri        RRLGGR-SLGYSSLRLLPKTTG--VRPILNLRRRMLQP-------GWAG-KAPFLGPSINSTITPIFN---VLNYEKARNPASLGSTLSFVGEIHTRLKSFKERLSQS-HSSDRRQPLYF 
Encephalitozoon cuniculi    -----STTHSYSELRCIPKMNG--ARIISNMSKAR------------------NGRPSINKSIYPEFC------VLRHETHGMLGNSILNHSGMYEKLSSYLSRSVRP---------LYI 

                                    850       860       870       880       890       900       910       920       930       940       950       960           
                            ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
structures                  --Motif A-----------------|                                                                                              
Schizosaccharomyces pombe   VRIDIKSCYDRIKQDLMFRIVKKKLKDPEFVIRKYATIHATS-----DRATKNFVSEAFSYFDMVP---------FEKVVQLLSMKTSDTLFVDFVDYWTKSSSEIFKMLKEHLSGHIVK 
Saccharomyces cerevisiae    MKFDVKSCYDSIPRMECMRILKDALKNENG---FFVRS----------QYFFNTNTGVLKLFN---------------VVNASRVPKPYELYIDNVRTVHLSNQDVINVVEMEIFKTALW 
Saccharomyces paradoxus     MKFDVKSCYDSIPRMECMRILKEALKSENG---FFVRS----------QSFFNTNTGVLKLVN---------------VVNASRVPKPYELYIDNVRTIHLSNQDVINVVEMEIFKTALW 
Saccharomyces mikatae       MKFDVESCYDSIPRIECMRIIKRALKSENG---FFVRS----------QYISNTNTGALKLVN---------------VVNASRTPKPYELYIDNVRTVHLSNQDVINVIEMEIFKTALW 
Saccharomyces kudriavzevii  MKFDVKSCYDSIPRTECMRIIKRALKKENG---FFVRS----------QSFFNTNTGILKLTN---------------VVNASRTPKPYELYIDNVRTVHLSNQDVIDVIEMETFKTALW 
Saccharomyces bayanus       MKFDVKSCYDSIPRTKSMQIIKRALENENG---FFVRS----------QSFFNTNTGVLRLVD---------------VVNASRTPKPHELYIDNVRTVHLSNQDVINVIEMEMFKTSLW 
Kluyveromyces lactis        LKFDIQSCYDSIPVQKVMKLVEARICEEQQ---FFIRS----------QDILTTASTRLKRLH---------------AVNGDIQFQENDLVIDSVKTTVLSKEDVLTVVKMELFKTSIF 
Candida albicans 1          LKFDMKECYDRLSQPVLMKKLEELFENQDNKTSYYVRYYAQLDASHKLKKVKTTIDTQYHNLN---------------ILSSSRHLSNCKSLVDKTKTIALQKGNILEVCRSQIYDVVGS 
Candida albicans 2          LKFDMKECYDRLSQPVLMKKLEELFENQDNKTSYYVRYYAQLDASHKLKKVKTTIDTQYHNLN---------------ILSSSRHLSNCKSLVDKTKTIALQKGNILEVCRSQIYDVVGS 
Ashbya gossypii             AKTDVKAAFDTIPQEAVVELMKSVPSQTNYTIMKHVEVKPGE---RAVIDDDKYSSKAIRRWHATALSENESSVFVERLEKDLAPKKKNTVFVDSAFRRTKNVGELMHLLRQHVEQNLVL 
Aspergillus fumigatus       VKLDIQSCFDTIPQKELIPLVESLFSEEGYQIGKHVEVRPPDEFSSMWPVQESQQSKALRKYVGRAAPVSKAQALTDAITDGGISHRRNTVFVDTPAHKEYSGDYLLDLLDEHIRYNLVK 
Aspergillus clavatus        VKVDIQSCFDTIPQENLVPLVESLVSEEGYYVAKHVEVRPSDEFSSMWPLHESQQSKALRKYVGRAAPVTNSQDLTEAIAEGGISHRRNTVFVDTVAHKEYSGDYLLDLLDEHIRYNLVR 
Aspergillus nidulans        VKLDIQSCFDTIPQAKIVRLVEKLVSEENYHWMKYVEMRLASEFDNMWPLRKPQQRRTWSKYLQRVGPVGRPENLADAIANGSVVGRRNTVLVDTIAQKEYNGEGLLDILNEHIRNNLVK 
Neosartorya fischeri        VKLDIQSCFDTIPQEELIPLIESLFSEEGYQIGKHVEVRPPDEFSSMWPVQESQQSKALRKYVGRAAPVSRAQDLTDAITDGGISHRRNTVFVDTPAHKEYSGDYLLDLLDEHIRYNLVK 
Encephalitozoon cuniculi    LKVDLSGCFDNIPQDEVVSLVRRLLHKSRYHTKSFSILEEVG--GELRSRYVCKVTENAETIN---------------ELMMEPGAFVNKVVKENASQRILSREEVEGAMTNMIKRNYVK 

                                    970       980       990       1000      1010      1020      1030      1040      1050      1060      1070      1080          
                            ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
structures                     |------------Motif B'------------------|        |----Motif C----||------Motif D------------|                 |-Motif  
Schizosaccharomyces pombe   IGNS-----QYLQKVGIPQGSILSSFLCHFYMEDLIDEYLSFTKKK--GSVLLRVVDDFLFITVNKKDAKKFLNLSLRG-FEKHNFSTSLEKTVINFENSNGIINNTFFNESKKRMPFFG 
Saccharomyces cerevisiae    VEDK-----CYIREDGLFQGSSLSAPIVDLVYDDLLEFYSEFKASPSQDTLILKLADDFLIISTDRQQVINIKKLAMGG-FQKYNAKANRDKILAVSSQSDDDTVIQ----------FCA 
Saccharomyces paradoxus     VEDK-----CYLREDGLFQGSSLSAPIVDLMYDDLLEFYGEFKTCPNQDTLILRLADDFLIISTDQQQIINIKNLASGG-FQKYNAKANEDKILAVSSHSDDDTVIQ----------FCA 
Saccharomyces mikatae       VQDK-----CYLREEGLFQGSCLSAPIVDLVYDDLLEFYDEFKSSSNQDTLILKLADDFLIISTDQQQIINVKKLAMDG-FEKYNAKVNRDKILSVCSPSDSGTVIQ----------FCA 
Saccharomyces kudriavzevii  VQDK-----CYLREDGLFQGSSLSAPIVDLVYDDLLEFYDEFKASPNQDTLILRLADDFLVISTDQQQISRIKKLAMGG-FEKYNAKANEDKIITVCSQPNNDTVIQ----------FCA 
Saccharomyces bayanus       IQDK-----CYLREDGLFQGSSLSAQIVDLVYDDLLESYNEFKASPNQDTLILRIADDFLIISTDQQQIIDIKNLATCG-FEEYNAKANEDKIITVSSQSNNDTIIQ----------FCA 
Kluyveromyces lactis        YRGK-----CYLRKDGLFQGTPLSSVLVDILYDDLLEFYTEFTDENDSDPMIIRLVDDFLIVSTSKKYIERLNNLAQTG-FKSFNTYINPQKVLVTSSESETSTNVP----------FCA 
Candida albicans 1          VKDARGNLHLYKRKRGVFQGFSLSSIFCDILYSAMVHDCFQFLWKSKQDFLFVRLVDDFLLVTPDSNIYDQVHNILSGKILESYGAFVNKDKTVVVN-QTTTKTSID----------FVG 
Candida albicans 2          VKDARGNLHLYKRKRGVFQGFSLSSIFCDILYSAMVHDCFQFLWKSKQDFLFVRLVDDFLLVTPDSNIYDQVHNILSGKILESYGAFVNKDKTVVVN-QTTTKPSID----------FVG 
Ashbya gossypii             VGKK-----YYRQKVGIPQGSVLSSFLCNYFYADLEAKHLGFLDSP--DCLLLRLIDDFLLVTLDQNKAAKFVNAMHGG-FPEYGVAVNPAKTMVNFDMLYAGEPVRNYNHEK-GFPYCG 
Aspergillus fumigatus       VGRK-----YFRQRNGIPQGSILSSVLCNLFYAQMERESLSFLDPS--EAVLLRLVDDFLLITINSNLAMRFLQVMLKG-QPKYGISINPAKSLVNFSAMVDGVQIPRLEGSH-LFPYCG 
Aspergillus clavatus        VGKK-----YFRQRNGIPQGSILSGVLCNLFYARMERECLGFLQSD--ESVLLRLIDDFLLVTTDSSLAMRFLQVMLKG-QPEYGITVNPAKSLVNFAAAVDGVQIPRLVDSA-LFPYCG 
Aspergillus nidulans        IGKK-----YFRQRKGIPQGSVLSSLLCSLLYAEMERDVLGFLQTD--DALLLRLLDDFLLVTLDSGLAMDFLRVMVRG-QPDYGISVNPAKSLVNFAAVVDGAQIPRLVDTP-LFPYCG 
Neosartorya fischeri        VGRK-----YFRQRNGIPQGSILSSVLCNLFYAQMERESLGFLDPS--EAVLLRLVDDFLLITTNSNLAMRFLQVMLKG-QPKYGISINPAKSLVNFSAAVDGVQIPRLEGSH-LFPYCG 
Encephalitozoon cuniculi    HNGK-----LFVQKTGIAQGSVASTLLCSLYYKSIDDLYFDRVFKEG---ILTRYVDDFLVISPCIDEIMKFLEVSQSI--SHLGINFSKEKMESNFGLEEHLKAAS---------SISE 

                                    1090      1100      1110      1120      1130      1140      1150      1160      1170      1180      1190      1200          
                            ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
structures                  E-|                                                                                                                      
Schizosaccharomyces pombe   FSVNMRSLDTLLACP-------KIDEALFNSTSVELTKHMGKSFFYKILRSSLASFAQVFIDITHNSKFNSCCNIYRLGYSMCMRAQAYLKRMKDIFIPQRMFITDLLNVIGRKIWKKLA 
Saccharomyces cerevisiae    MHIFVKELEVWKHSS--------------TMNNFHIRSKSSKGIFRSLIALFNTRISYKTIDTNLNSTNTVLMQIDHVVKNISECYKSAFKDLSINVTQNMQFHSFLQRIIEMTVSGCPI 
Saccharomyces paradoxus     MHIFVKKLEVWKHSS--------------TMNNFNIRSSSSKRIFRSLIALFNTRISYKTVDSNLNSTTTVLMQIHHVVKNISEGYKSAFKDLSINDRESMQFSSFLLRIIEMTVDACPI 
Saccharomyces mikatae       MYISIKNLEVWKHSS--------------TMNIFNIHSSSSKKIFRSLIALFNTRLSYKTIDPDLNSITTVLMQIHHIVKNISESYKFAFRDLSINDTQNNHFSSFLLRIIEMTLDVYSI 
Saccharomyces kudriavzevii  MHIFIKELEVWKHSS--------------TMNIFNIRSNSSKKIFGRLISLFNTRISYKTADSNLNSITTVLMQIYHIVKNISESYKSAFKDLSMNDTQNIQFSSFLLRIIKMTLDVCLI 
Saccharomyces bayanus       MHIFIKELEIWKHSN--------------TMNVFNVRSNSSKIIFRRLTSLFNTRVSYKTINYNLNSTATVLMQIYYIVKNISEGYKFAFKDLPINNTQNVQFSLFLSNIIEMTLDICPA 
Kluyveromyces lactis        LQLNLRTLEVWKDRS--------------SYNVLGTVLGSSKQLYNKLLWIFEMRLSYNMLDERLNSWETAARFLREVALNVIQSFIVLFNRKKSSRRSFKQFVFNIFQRIDLNLSSANM 
Candida albicans 1          LEVNTTDLSIKRNSG--------------SISLVTTNFRTFKTLVKYLKTFYQLNLEGFLLDCSFGVLENVLENMGSLLRLVLREFKTKFTSIVKYDT----FHCYKFIKFLYDISNYTI 
Candida albicans 2          LEVNTTDLSIKRNSG--------------SISLVTTNFRTFKTLVKYLKTFYQLNLEGFLLDCSFGVLENVLENMGSLLRLVLREFKTKFTSIVKYDT----FHCYKFIKFLYDISNYTI 
Ashbya gossypii             TAINCQTLDITKDRERDAN-----------------------------IDAFKIQSHLMFYDTSHNSTRTVLSSLQGAFVETASKMLAYLRCLGKNQHPSSEMILRTIAKVIDVAYLLLT 
Aspergillus fumigatus       SLIDTRTLEIYRDQDRILEGTDSAAGTISSSLTVEFTRAPGRSLHRKVLSSFKLQMHPMYLDTKHNSLTVVLWNLYANLVTSAMKMYRYMKALPHRAHPTPEVVIRVIRDLIELAHRMMR 
Aspergillus clavatus        SLINTATLEIYRDPERVVEGGDSAAATLASSLTVESARAPGRSLHRKMLSAFKLQMHPMYLDTQHNSLSAVLSNLYASFVTAAMKMYQYMKALPRRAHPTAEVMARVIRDLMYLAHRMVG 
Aspergillus nidulans        SLIDTRTLEIFRDQDRMLEGADSASVALSDSLSIDSTRTPGRSFYRKVLASIKQSMHPMYLDSTHNSLPAVLLNVYKSFVTAAMKMYRYTRSLPGRARPRPEVVVRTIHDATQLGYRLIR 
Neosartorya fischeri        SLIDTRTLEIYRDQDRILEGTDSAAATISSSLTVESTRAPGRSLHRKVLSSFKLQMHPMYLDTKHNSLNVVLWNLYANLVTSAMKMYRYMKALPHRAHPTPDVVIRVIQDLIELAHRMMR 
Encephalitozoon cuniculi    LSKHKHSMKITNAPVG------------------WCGTKIYSDGFSIKSQTADPYLPFSIAHSSTKPGRALESRMRKLLQNRMSRIYIDPNNKKAYENIYDTFLFYGKKLGLLLGRMDFI 

                                    1210      1220      1230      1240      1250      1260      1270      1280            
                            ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|..
structures                                                                                                          
Schizosaccharomyces pombe   EILG-----------YTSRRFLSSAEVKWLFCLGMRDGLKP-SFKYHPCFEQLIYQFQSLTDLIKPLRPVLRQVLFLHRRIAD---- 
Saccharomyces cerevisiae    TKCD----------------PLIEYEVRFTILNGFLESLSSNTSKFKDNIILLRKEIQHLQAYIYIYI------------------- 
Saccharomyces paradoxus     TKCD----------------PLIEYEVRFAILNGFLESLSSNASKFKNNIILLRKEIQHLQPHIYT--------------------- 
Saccharomyces mikatae       TRLD----------------PLIGYEVRFTILNGFLKSFSSNTSKFKNNILFLEKEIQHLQMYVVS--------------------- 
Saccharomyces kudriavzevii  TRCD----------------PLIEYEVRYTILNGFLESLCSNASRFKKNIIFLREEIQHLQAYI----------------------- 
Saccharomyces bayanus       MKYD----------------LFTEREVRCTILSGFLENLSSNTSKFKDNINYLRGEIQSLQVYI----------------------- 
Kluyveromyces lactis        FSME----------------KSVASKE--LVLSVFLEQLKLRKNAFADILTNVSDLKLLIEF------------------------- 
Candida albicans 1          VKYV----------------ETNSDWEGAPELLNCIKQIIVKEFSSFESYSEIVEWVQTLNI------------------------- 
Candida albicans 2          VKYV----------------ETNSDWDGAPELLNCIKQIIVKEFSSFESYSEIVEWVQTLNI------------------------- 
Ashbya gossypii             SKS-------RIMKYPQYTCDIRKSQVALTACLAFEKVLAAKQSNYQPVVKWLR---KEADRLASGRKHKSIHTPRSGQASG----- 
Aspergillus fumigatus       ARR---ELK-SRDSCSPYMCLVQQQQVRYLAAAAFRFVLGRKQTKYAKVLRWLEQVWKAARPQSDGKAARLAEVVRNGNSVFASWRF 
Aspergillus clavatus        ARR---ELHTARGPGSPSLCLVQGAQVQYLATAAFRFVLGRKQTKYAGVLRWLEQVWKAARPPSSAKAMRLAQVVRQGNASFAGWRF 
Aspergillus nidulans        GRHG--------------LCRVTHPQLQYLGGAAFQFVLGRKQTQYAGVLRWLDGTLAEAR-QSVGNSVLLAQAVQKGNRTYREWRF 
Neosartorya fischeri        ARR---ELK-SRDSCSPYMCLVQQQQVQYLAAAAFRFVLGRKQTKYAKVLRWLEQVWKAARPQSDGKAARLAQVVRNGNSVFASWRF 
Encephalitozoon cuniculi    NRSFAR--------------RTLEHSKRFAFRICRKHGISITRKKIEDIASRAFDQSGVSRIVLTP---------------------