10        20        30        40        50        60        70        80        90       100       110       120                    
                         ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
structures                                                                                                                                        
Tetrahymena thermophila  ---------------------------------MQKINNINNNKQMLTRK---------------------EDLLTVLKQISALKYVSNLYEFLLATEKIVQTS---------ELDTQFQ 
Paramecium tetraurelia   -------------------------------------------------------------------------MLFTLKNIQQFQSVFTFQQYLLFIG---------------AEFDQNT 
Paramecium caudatum      -------------------------------------------------------------------------MLITLQQIAQLYNVITLQDYLKYLD---------------VDPPKN- 
Euplotes aediculatus     -------------------------------------MEVDVDNQADN-----------------------HGIHSALKTCEEIKEAKTLYSWIQKVIRCRNQSQS-----HYKDLEDIK 
Oxytricha trifallax      MSAKKPVQSKLNIGNPTIPVTSNRSTAPKPVPGQPQFVNQEKKQQSQNTTTGAFRSNQNNANSGGNGNFELDDLHLALKSCNEIGSAKTLFCFFMELQKINDKIPSKKNTELIKNDPQFQ 

                                 130       140       150       160       170       180       190       200       210       220       230       240           
                         ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
structures                                                                                                                         |------------- 
Tetrahymena thermophila  EFLTTTIIASEQNLVEN---YKQKYNQPNFSQLTIKQVIDDSIILLGNKQN-----YVQQIGTTTIGFYVEYENINLSRQ-----------------------TLYSSNFRNLLNIFGEE 
Paramecium tetraurelia   IFYQTTLICSDNIP-------LKKFPIIKPSNFLYQKLFEEKKKDEN-----------KCIQYSNNENNFQNKKYFLVSQK----------------------LILSDEMETFYKIVGEQ 
Paramecium caudatum      IFFQNTIICSETQN-------LQKFPIKKPLNFLYQKLSDDQRRDE-------------IVTDSRNDFQFQKQKSFIGCQK----------------------LMLSDNMEHLYREIGEQ 
Euplotes aediculatus     IFAQTNIVATPRDYNEEDFKVIARKEVFST--GLMIELIDKCLVELLSSSDVSDRQKLQCFGFQLKGNQLAKTHLLTALST-------------------QKQYFFQDEWNQVRAMIGNE 
Oxytricha trifallax      YFCHNTILCTEQSYDEKTIEKLAKLEYKLEYKNSYIDMISKVIKELLIENKLN---KLQTFGYKLVNNEFGNQNHLGMMQQNQDSSHNSNFMVKCDYINLNKQCMITKNWEKVYFYLGDH 
                                                                                                                                |---------------- 

                                 250       260       270       280       290       300       310       320       330       340       350       360           
                         ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
structures               ---Motif T2------------------|                                                                                 |----CP2- 
Tetrahymena thermophila  DFKYFLIDFLVFTK--VEQNGYLQVAGVCLNQYFSVQVKQKKWYKNNFNMNGKATSNNNQNNANLSNEKKQE------------------------------NQYIYPEIQRSQIFYCNH 
Paramecium tetraurelia   NIDFILQNFKILIKEDTNKETYIQIWGEPIMKNTIKQ-----------------------------------------------------------------KSNNQEKICRQQILYCNH 
Paramecium caudatum      NFDYLLKNYKILIKDDNDSETYIQISGDPIMKIQPKQ-----------------------------------------------------------------KQQIAEKIQRQQILYCNH 
Euplotes aediculatus     LFRHLYTKYLIFQR--TSEGTLVQFCGNNVFDHLKVN--------------DKFDKKQKGGAADMNEPRCCS------------TCKYNVKNEKDHFLNNINVPNWNNMKSRTRIFYCTH 
Oxytricha trifallax      LFMHIYKEYMIFLK--TRDESLVQISGTNIFCYLNEKLGRLQAAFYEGPNKNAANSAAQGSNPEANDLISAEQRKINTAIVMKKTHKYNIKAADESYLTNQEKGFWDDQIKRNRLFYCAH 
                         ---Motif N-------------------|                                                                                           

                                 370       380       390       400       410       420       430       440       450       460       470       480           
                         ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
structures               --|                                                                            |------Motif CP-------------|             
Tetrahymena thermophila  MGREPGVFKSSFFNYSEIKKGFQFKVIQEKLQGRQFINSDKIKPDHPQTIIKKTLLKEYQSKNFSCQEERDLFLEFTEKIVQNFHNINFNYLLKKFCKLPENYQSLKSQVKQIVQSENKA 
Paramecium tetraurelia   MSRQVGFFKKNFISQAKKEIIMRNFIPKEQISN-----------EMISMKATSNIFDQCFFEGKFKEQEKQQLRILTQKLITNMQKFNFPQAFKIFVPLPTNYLNLKKEVSQSIK----Q 
Paramecium caudatum      MSRQVGMFKKNFISYAKKQIIKSNYIKMQQITP-----------EIIAIKSTSNILDYFYNNKQLSPIEISHLRPILESCMKKLQKFNFHGQFKFFVPLPSNYKQLKQETKRHLK----D 
Euplotes aediculatus     FNRNNQFFKKHEFVSN--------KNNISAMDRAQTIFTNIFRFNRIRKKLKDKVIEKIAY------------------MLEKVKDFNFNYYLTKSCPLPENWRERKQKIENLIN----K 
Oxytricha trifallax      QNR---FFQKHILNS----------KTLSQQQIRDNIYKEVFGFNRVRAELKGKVMSIIEQ------------------VIVNQKKFDFKYYLSKNCPLPENWKNLKKSFLEDAA----V 

                                 490       500       510       520       530       540       550       560       570       580       590       600           
                         ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
structures                                                                                                                          |------------ 
Tetrahymena thermophila  NQQSCENLFNSLYDTEISYKQITNFLRQIIQNCVPNQLLGKKNFKVFLEKLYEFVQMKRFENQKVLDYICFMDVFDVEWFVDLKNQKFTQKRKYISDKRKILGDLIVFIINKIVIPVLRY 
Paramecium tetraurelia   NLYYIPNLYDEIYKNFLSYDQVISILRYFLRTIIPIDFLGQSNLYTFLKDLSQFITFLRFEDQNYLDYINRLNVFQIPWMNSYFSK--KKQKILISKKRQQLLPIFRFLFQLIIIPFLRH 
Paramecium caudatum      SLN-VSQLLDHLYLNHIPHQQITSLVRNFLREIIPIDLFGQQNLFTFLTDISDFITLLRFEDQSYLDYIKKMNVFEVPWLNKYFNK--KKQRLLIIKKRNQMIPLMKFMFQEIIIPFLRH 
Euplotes aediculatus     TREEKSKYYEELFSYTTDNKCVTQFINEFFYNILPKDFLTGRNRKNFQKKVKKYVELNKHELIHKNLLLEKINTREISWMQVETSA--KHFYYFDHENIYVLWKLLRWIFEDLVVSLIRC 
Oxytricha trifallax      SGELRGQVFRQLFEYQQDQRQISNFLTEFVANVFPKNFLEGKNKKIFNKKMLQFVKFNRFESFTKISLLNKFRVNEVSWLSFKCKD--ENKKFFMNENEHVFFKVLKWVFEDLAITLMRC 

                                 610       620       630       640       650       660       670       680       690       700       710       720           
                         ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
structures               --------Motif T-------------------|                       |-Motif 1||-------Motif 2-----|                                
Tetrahymena thermophila  NFYITEKHKEGSQIFYYRKPIWKLVSKLTIVKLEEENLEKVEEKLIPEDS-FQKYPQGKLRIIPKKGSFRPIMTFLRKDKQKNIKLNLNQILMDSQLVFRNLKD-----MLGQKIGYSVF 
Paramecium tetraurelia   NFYITERMKDDWKLFYYRKEIWTLVLKLSLNQLSSNNLKQISPEKITTQY------IGKLRIVPKPGTFRPIVTYNRKSRISKLSLNKKLLDIKYVLRNLR-----SQQLGFSVFGNPQI 
Paramecium caudatum      NFYITERMKDDWKLFYYRKEIWHLILQLSLTSLTKNNFEEISVNSIKTPY------VGKLRIVPKPGTFRPIVTYNRKAKTSKISLNRKLVDIKYILRNLR-----IQPLGYSVFGNPEV 
Euplotes aediculatus     FFYVTEQQKSYSKTYYYRKNIWDVIMKMSIADLKKETLAEVQEKEVEEWKKSLGFAPGKLRLIPKKTTFRPIMTFNKKIVNSD-RKTTKLTTNTKLLNSHLMLKTLKNRMFKDPFGFAVF 
Oxytricha trifallax      YFYSTEKAKEYQRIFYYRKNIWNMIMRLSIDDLLKQNLKQVEKKEMRIFCESQNFAPGKLRLIPKGDTFRPIMTFNRKIPNQVGKFQSRMTTNNKLQTAHMMLKNLKSKMFKHSFGFAVF 

                                 730       740       750       760       770       780       790       800       810       820       830       840           
                         ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
structures                                    |--------Motif A---------|                                                                          
Tetrahymena thermophila  DNKQISEKFAQFIEKWKNKGRPQLYYVTLDIKKCYDSIDQMKLLNFFNQSDLIQDTYFINKYLLFQRNKRPLLQIQQTNNLNSAMEIEEEKINKKPFKMDNINFPYYFNLKERQIAYSLY 
Paramecium tetraurelia   FNRLEEFKKLWIKYQF-----PQTYFMSMDIHKCYDSIQLEFLLKFIEESNLIQSAYVINKYYLIIRNNR---------------------QSRGS-----KQMRELFNIFDRTCAIPIN 
Paramecium caudatum      FSRLEEFKKLWIKLQQ-----PKTYYITMDIQKCYDTIILQKLLQFIEESKQFSSIYAINKYHIVSRNNR---------------------MLKPS-----FSMKDLFNILDRTCAIPFN 
Euplotes aediculatus     NYDDVMKKYEEFVCKWKQVGQPKLFFATMDIEKCYDSVNREKLSTFLKTTKLLSSDFWIMTAQILKRKNN---------------------IVIDSKNFRKKEMKDYFRQKFQKIALEGG 
Oxytricha trifallax      NYDDIMKRYENFVQKWKQINSPKLYFVAMDIEKCYDNVDCERVVNFLQKSDLMDKEYFILNTFVLKRKNN---------------------IIVERSNFRKLPIKQYFRYKFQKIGIDGS 

                                 850       860       870       880       890       900       910       920       930       940       950       960           
                         ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
structures                                                                         |--------Motif B'--------|                    |--Motif C--|    
Tetrahymena thermophila  DDDDQILQKGFKEIQS--DDRPFIVINQDKPRCITKDIIHNHLKHISQYNVISFNKVKFRQKRGIPQGLNISGVLCSFYFGKLEEEYTQFLKN--AEQVNGSINLLMRLTDDYLFISDSQ 
Paramecium tetraurelia   NP--QALQKGYIEYIQ--QNKLAIIANLGIQTTVTFSEFLLSIKELCQNNIVQFEDRYFIQTLGIPQGLNISGILCSFYIANIEKN---------LTRKLIGDTLIMRLTDDYCCLTFDK 
Paramecium caudatum      KP--QLLQKGYIEHIQ--KNKQTIIINQGFQNSVTFSEFLNSIKNICQNNIVQFENRYFRQTLGIPQGLNISGILCSFYLANLEQK---------LTNKILGDTLIMRLTDDYCCLAFSQ 
Euplotes aediculatus     QY--PTLFSVLENEQNDLNAKKTLIVEAKQRNYFKKDNLLQPVINICQYNYINFNGKFYKQTKGIPQGLCVSSILSSFYYATLEESSLGFLRDESMNPENPNVNLLMRLTDDYLLITTQE 
Oxytricha trifallax      SY--PTLFEILEDEFNDLNMKRTIIVEQEQRKKFPKNDLLQPVLKICQNNYVTFNKKQYKQMKGIPQGLCVSYILSSFYYANLEENALQFLRKESMDPEKPEINLLMRLTDDYLLMTTEK 

                                 970       980       990       1000      1010      1020      1030      1040      1050      1060      1070      1080          
                         ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
structures                 |----------Motif D--------|                           |--Motif E--|                                                    
Tetrahymena thermophila  QNALNLIVQLQNCANNNGFMFNDQKITTNFQFPQEDYN-----LEHFKISVQNECQWIGKSIDMNTLEIKS-IQKQTQQEINQTINVAISIKNLKSQLKNKLRSLFLNQLIDYFNPNINS 
Paramecium tetraurelia   QNLITIKNNFKEVEKQYSIHLNDDKTQHNIDQK------------------IVSFKWIGKIINLDKLTLKPAFAQEKDSKFSNQINVNLPSRINSYFFKAKLKSLMLNQFKFFFNPKIND 
Paramecium caudatum      DSSIKILNNFTQIEKQYQIRLNHDKTQHNIERS------------------DRYFKWIGKIIDIETLTLKPAFYLESDTKFQYQINVNLPTKVKTYYIKSKLKSLILNQFKFFFNSKLND 
Euplotes aediculatus     NNAVLFIEKLINVSRENGFKFNMKKLQTSFPLSPSKFAKYGMDSVEEQNIVQDYCDWIGISIDMKTLALMPNINLRIEG-ILCTLNLNMQTKKASMWLKKKLKSFLMNNITHYFRKTITT 
Oxytricha trifallax      NNAMLFIEKLYQLSLGNFFKFHMKKLKTNFALNLQKIG-CTNTTQDIDSINDDLFHWIGISIDIKTLNIIQNINIKKEG-ILCTLNVNMQTNESILWLKKKLKSFLMNNISFYFKSTINT 

                                 1090      1100      1110      1120      1130      1140      1150      1160      1170      1180      1190      1200          
                         ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
structures                                                                                                                                        
Tetrahymena thermophila  FEGLCRQLYHHSKATVMKFYPFMTKLFQIDLKKSKQYSVQYGKENTNENFLKDILYYTVEDVCKILCYLQFEDEINSNIKEIFKNLYSWIMWDIIVSYLKKKKQFKGYLNKLLQKIRKSR 
Paramecium tetraurelia   QPTLIKIAKTFIHAGLIKLINFMEKAKL-FKVSK----------QKS--NKIDFLKIIKQVQIEIANYCFQQAQERGSELD--QNYILRIIKKQLQKTIKNHKKLKTIINYKNL------ 
Paramecium caudatum      KPTMIKVLKIFVHSGLVKLISFLKRLKYNYGASK----------LRNQGKSIRLLKIIKEIKVEIAAYCVQQSRESNMEID--QEYLMRIIQKQLKKTIRNNSYLRKKINYKQI------ 
Euplotes aediculatus     EDFANKTLNKLFISGGYKYMQCAKEYKDHFKKNL----------AMSSMIDLEVSKIIYSVTRAFFKYLVCNIKDTIFGEEHYPDFFLSTLKHFIEIFSTKKYIFNRVCMILKAKEAKLK 
Oxytricha trifallax      KQFANITLSKLYIAAAEKYVACCQEFKRFHENTS----------LGGQNIDIKIIHIIYVVIRSFFKYLVCNVKSPVFERDDYQQFFIYSLKFFITRFKQQKNEFAGVYKILKAKEKKLE 

                                 1210      1220      1230      1240      1250          
                         ....|....|....|....|....|....|....|....|....|....|....|....
structures                                                                                                                                        
Tetrahymena thermophila  FFYLKEGCKSLQLILSQQKYQLNKKELEAIEFIDLNNLIQDIKTLIPKISAKSNQQNTN                                                              
Paramecium tetraurelia   -----------------------------------------------------------                                                              
Paramecium caudatum      -----------------------------------------------------------                                                              
Euplotes aediculatus     SDQCQSLIQYDA-----------------------------------------------                                                              
Oxytricha trifallax      VAKIEFQIQ--------------------------------------------------